F
Florence Baudin
Researcher at European Bioinformatics Institute
Publications - 61
Citations - 5610
Florence Baudin is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: RNA & Transcription (biology). The author has an hindex of 31, co-authored 56 publications receiving 5182 citations. Previous affiliations of Florence Baudin include Centre national de la recherche scientifique & Unit of Virus Host Cell Interactions.
Papers
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Journal ArticleDOI
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Alexandre Dias,Denis Bouvier,Thibaut Crépin,Andrew A. McCarthy,Darren J. Hart,Florence Baudin,Stephen Cusack,Rob W.H. Ruigrok +7 more
TL;DR: In this paper, the amino-terminal 209 residues of the PA subunit contain the active site of the endonuclease active site, which is shown to be strongly activated by manganese ions, matching observations reported for the intact trimeric polymerase.
Journal ArticleDOI
Probing the structure of RNAs in solution
Chantal Ehresmann,Florence Baudin,Marylène Mougel,Pascale Romby,Jean-Pierre Ebel,Bernard Ehresmann +5 more
TL;DR: In this paper, the various structure probes used so far are described, and their utilization is discussed.
Journal ArticleDOI
Functional Sites in the 5′ Region of Human Immunodeficiency Virus Type 1 RNA Form Defined Structural Domains
Florence Baudin,Roland Marquet,Catherine Isel,Jean-Luc Darlix,Bernard Ehresmann,Chantal Ehresmann +5 more
TL;DR: The conformation of the first 500 nucleotides covering the RNA leader and the 5' gag coding sequences of HIV-MAL, using chemical probing, shows the structural versatility of this region and suggests two mutually exclusive structures could modulate the different functions involving this domain.
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Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit
Franck Tarendeau,Julien Boudet,Delphine Guilligay,Philippe J. Mas,Catherine M. Bougault,Sébastien Boulo,Florence Baudin,Rob W.H. Ruigrok,Nathalie Daigle,Jan Ellenberg,Stephen Cusack,Jean-Pierre Simorre,Darren J. Hart +12 more
TL;DR: It is shown that both the domain and the full-length PB2 subunit are efficiently imported into the nucleus dependent on a previously overlooked bipartite nuclear localization sequence (NLS).
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Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent.
TL;DR: The results suggest that the nucleoprotein binds to the vRNA backbone without apparent sequence specificity, exposing the bases to the outside and melting all secondary structure, and the viral polymerase may transcribe the RNA without the need for dissociating theucleoprotein and without being stopped by RNA secondary structure.