D
Denis Bouvier
Researcher at Centre national de la recherche scientifique
Publications - 12
Citations - 994
Denis Bouvier is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Cap snatching & Polymerase. The author has an hindex of 9, co-authored 12 publications receiving 901 citations. Previous affiliations of Denis Bouvier include Unit of Virus Host Cell Interactions & University of Nebraska Medical Center.
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Journal ArticleDOI
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Alexandre Dias,Denis Bouvier,Thibaut Crépin,Andrew A. McCarthy,Darren J. Hart,Florence Baudin,Stephen Cusack,Rob W.H. Ruigrok +7 more
TL;DR: In this paper, the amino-terminal 209 residues of the PA subunit contain the active site of the endonuclease active site, which is shown to be strongly activated by manganese ions, matching observations reported for the intact trimeric polymerase.
Journal ArticleDOI
Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains.
Denis Bouvier,Gaelle Spagnol,Sylvie Chenavas,Fabien Kieken,Heidi Vitrac,Sarah Brownell,Admir Kellezi,Vincent Forge,Paul L. Sorgen +8 more
TL;DR: These studies support the “particle-receptor” model for pH gating of Cx40 and Cx43 gap junction channels and suggest that interactions between cytoplasmic regulatory domains (both homo- and hetero-connexin) could be important for the regulation of heteromeric channels.
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Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α.
Elise Delaforge,Elise Delaforge,Sigrid Milles,Sigrid Milles,Guillaume Bouvignies,Guillaume Bouvignies,Denis Bouvier,Stephane Boivin,Stephane Boivin,Nicola Salvi,Nicola Salvi,Damien Maurin,Damien Maurin,Anne Martel,Adam Round,Edward A. Lemke,Malene Ringkjøbing Jensen,Malene Ringkjøbing Jensen,Darren J. Hart,Darren J. Hart,Martin Blackledge,Martin Blackledge +21 more
TL;DR: This intrinsic large-scale conformational flexibility enables 627-NLS to bind importin through conformational selection from a temperature-dependent equilibrium comprising both functional forms of the protein.
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Macro to microfluidics system for biological environmental monitoring
Cyril Delattre,Cédric Allier,Yves Fouillet,Dorothée Jary,Frederic Bottausci,Denis Bouvier,Guillaume Delapierre,Manuelle Quinaud,Arnaud Rival,Laurent Davoust,Christine Peponnet +10 more
TL;DR: This paper discusses an original fluidic architecture based on three connected modules, a sampling module, a sample preparation module and a detection module, which is a PCR based miniaturized platform using digital microfluidics.
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MAP6-F Is a Temperature Sensor That Directly Binds to and Protects Microtubules from Cold-induced Depolymerization
Christian Delphin,Denis Bouvier,Maxime Seggio,Emilie Couriol,Yasmina Saoudi,Eric Denarier,Christophe Bosc,Odile Valiron,Mariano Bisbal,Isabelle Arnal,Annie Andrieux +10 more
TL;DR: It is shown that in the absence of MAP6, microtubules in cells below 20 °C rapidly depolymerize in a temperature-dependent manner whereas they are stabilized in the presence ofMAP6, suggesting a direct effect of the temperature on the formation of microtubule/MAP6 complex.