F
Florence de Fraipont
Researcher at University of Grenoble
Publications - 56
Citations - 3033
Florence de Fraipont is an academic researcher from University of Grenoble. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 29, co-authored 51 publications receiving 2744 citations. Previous affiliations of Florence de Fraipont include Joseph Fourier University & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro
C. Moriscot,Florence de Fraipont,Marie-Jeanne Richard,Mélanie Marchand,Mélanie Marchand,Pierre Savatier,Pierre Savatier,Domenico Bosco,Marie Favrot,Pierre‐Yves Benhamou +9 more
TL;DR: The results demonstrated that in vitro human bone marrow stem cells are able to differentiate into insulin‐expressing cells by a mechanism involving several transcription factors of the beta‐cell developmental pathway when cultured in an appropriate microenvironment.
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Gene Expression Profiling of Human Adrenocortical Tumors Using Complementary Deoxyribonucleic Acid Microarrays Identifies Several Candidate Genes as Markers of Malignancy
Florence de Fraipont,Michelle El Atifi,Nadia Cherradi,Gwennaelle Le Moigne,G. Defaye,Rémi Houlgatte,Jérôme Bertherat,Xavier Bertagna,Pierre-François Plouin,Eric Baudin,François Berger,Christine Gicquel,Olivier Chabre,Jean-Jacques Feige +13 more
TL;DR: The parallel analysis of the expression levels of a selected group of genes on microgram quantities of tumor RNA appears as a complementary method to histopathology for the diagnosis and prognosis of evolution of adrenocortical carcinomas.
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MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function
Andrés Caicedo,Vanessa Fritz,Jean-Marc Brondello,Mickaël Ayala,Indira Dennemont,Naoill Abdellaoui,Florence de Fraipont,Anaïck Moisan,Claire Angebault Prouteau,Hassan Boukhaddaoui,Christian Jorgensen,Marie-Luce Vignais +11 more
TL;DR: The transfer of minute amounts of mesenchymal stem/stromal cell (MSC) mitochondria to cancer cells, a process otherwise occurring naturally in coculture, results in cancer cell enhanced oxidative phosphorylation (OXPHOS) activity and favors cancer cell proliferation and invasion.
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Dual IHC and FISH Testing for ALK Gene Rearrangement in Lung Adenocarcinomas in a Routine Practice: A French Study
Anne McLeer-Florin,Denis Moro-Sibilot,Adrien Melis,Dimitri Salameire,Christine Lefebvre,Françoise Ceccaldi,Florence de Fraipont,Elisabeth Brambilla,Sylvie Lantuejoul +8 more
TL;DR: In this article, the authors evaluated IHC as a prescreening tool for adenocarcinomas and found that IHC can lead to intense cytoplasmic staining in 6.5% of the cases screened.
Journal ArticleDOI
Temozolomide Treatment in Aggressive Pituitary Tumors and Pituitary Carcinomas: A French Multicenter Experience
Gérald Raverot,Nathalie Sturm,Florence de Fraipont,M. Muller,Sylvie Salenave,Philippe Caron,Olivier Chabre,Philippe Chanson,Christine Cortet-Rudelli,Richard Assaker,Henry Dufour,Stephan Gaillard,Patrick François,Emmanuel Jouanneau,Jean-Guy Passagia,Michèle Bernier,Aurélie Cornelius,Dominique Figarella-Branger,Jacqueline Trouillas,Françoise Borson-Chazot,Thierry Brue +20 more
TL;DR: In this paper, the authors describe the antitumoral efficacy and toxicity of temozolomide in patients with aggressive pituitary tumors or carcinomas and evaluate the possible prognostic value of MGMT promoter methylation and protein expression.