Florian Schellauf

TL;DR: The public health benefits of sunscreens containing nano TiO(2) and/or ZnO outweigh human safety concerns for these UV filters, and the in vitro genotoxic and photogenotoxic profiles of these nano-structured metal oxides are of no consequence to human health.

TL;DR: The safety assessments for skin irritation/corrosion of new chemicals for use in cosmetics can be confidently accomplished using exclusively alternative methods.

TL;DR: Common approaches of cosmetic companies are described, with recommendations for evaluating in vitro genotoxins using non-animal approaches and a weight of evidence approach was employed to set up a decision-tree for the integration of alternative methods into tiered testing strategies.

TL;DR: It was evaluated how and when non-animal test methods, predictions based on physico-chemical properties, threshold concepts and weight-of-evidence based hazard characterisation could be used to enable safety decisions.