Marilyn J. Aardema

TL;DR: It was possible to establish that positive results in all three tests indicate the chemical is greater than three times more likely to be a rodent carcinogen than a non-carcinogen, and a relative predictivity (RP) measure is a useful tool to assess the carcinogenic risk from a positive genotoxicity signal.

TL;DR: The consensus agreement on the protocol for performing the in vitro micronucleus assay is presented in this paper, where the major recommendations concern: 1. Demonstration of cell proliferation: both cell lines and lymphocytes can be used, but demonstration of the cell proliferation in both control and treated cells is compulsory for the acceptance of the test.

TL;DR: The guidelines for the conduct of specific aspects of the protocol were developed at the Washington International Workshop on Genotoxicity Test Procedures (March 25-26, 1999), the current methodologies and data for the in vitro micronucleus test were reviewed as mentioned in this paper.

TL;DR: It was concluded that better guidance on the likely mechanisms resulting in positive results that are not biologically relevant for human health, and how to obtain evidence for those mechanisms, is needed both for practitioners and regulatory reviewers.

TL;DR: Toxicogenomics is defined as “the study of the relationship between the structure and activity of the genome (the cellular complement of genes) and the adverse biological effects of exogenous agents”, and there are powerful new methods for protein analysis and for analysis of cellular small molecules.