F
Franca Ronchese
Researcher at Malaghan Institute of Medical Research
Publications - 12
Citations - 1974
Franca Ronchese is an academic researcher from Malaghan Institute of Medical Research. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 11, co-authored 12 publications receiving 1777 citations. Previous affiliations of Franca Ronchese include National Institutes of Health.
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Journal ArticleDOI
A2A adenosine receptor protects tumors from antitumor T cells
Akio Ohta,Elieser Gorelik,Simon J. Prasad,Franca Ronchese,Dmitriy Lukashev,Dmitriy Lukashev,Michael K.K. Wong,Michael K.K. Wong,Xiaojun Huang,Sheila A. Caldwell,Kebin Liu,Kebin Liu,Patrick F. Smith,Jiang-Fan Chen,Edwin K. Jackson,Sergey Apasov,Scott I. Abrams,Michail V. Sitkovsky,Michail V. Sitkovsky +18 more
TL;DR: Although using the hypoxia→adenosine→A2AR pathway inhibitors may improve antitumor immunity, the recruitment of this pathway by selective drugs is expected to attenuate the autoimmune tissue damage.
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
TL;DR: The analysis of the response of a T helper type 1 clone to mutant E alpha E beta k molecules in the absence or presence of a peptide antigen revealed that peptide inhibited the interleukin 2 response to an otherwise allostimulatory mutant form of this MHC class II molecule.
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CD8+ T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor Immunity
TL;DR: It is shown that CTL-mediated clearance of Ag-loaded DC has a notable effect on immune responses in vivo and may serve as a negative feedback mechanism to limit the activity of DC within the lymph node.
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Differential T cell function and fate in lymph node and nonlymphoid tissues.
TL;DR: Activated T cells can undergo clonal expansion in the lymph node, but are recruited and retained as nondividing cells in nonlymphoid tissues, revealing simple key mechanisms for both inducing and limiting T cell immunity.
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The role of B7 costimulation in T-cell immunity
Nicola L. Harris,Franca Ronchese +1 more
TL;DR: The present review outlines the current understanding of the physiological role of B7 costimulatory signals in regulating CD4+ T cell responses and identifies two major signalling pathways responsible for delivery.