F
Frances M. Leslie
Researcher at University of California, Irvine
Publications - 149
Citations - 14109
Frances M. Leslie is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Nicotine & Nicotinic agonist. The author has an hindex of 60, co-authored 144 publications receiving 13161 citations. Previous affiliations of Frances M. Leslie include University of California & University of California, Berkeley.
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Journal ArticleDOI
Brain monoglyceride lipase participating in endocannabinoid inactivation
Thien P. Dinh,D. Carpenter,Frances M. Leslie,Tamás F. Freund,István Katona,Stefano L. Sensi,Satish Kathuria,Daniele Piomelli +7 more
TL;DR: The results suggest that hydrolysis by means of MGL is a primary mechanism for 2-AG inactivation in intact neurons, and not on the accumulation of anandamide, another endocannabinoid lipid.
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Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
Michelle Y. Cheng,Clayton M. Bullock,Chuanyu Li,Alex G. Lee,Jason C. Bermak,James D. Belluzzi,David R. Weaver,Frances M. Leslie,Qun-Yong Zhou +8 more
TL;DR: It is shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the suprachiasmatic nucleus (SCN) circadian clock.
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Molecular characterization of the melanin-concentrating-hormone receptor
Yumiko Saito,Hans Peter Nothacker,Zhiwei Wang,Steven H. Lin,Frances M. Leslie,Olivier Civelli +5 more
TL;DR: It is shown that the natural ligand of this receptor is the neuropeptide melanin-concentrating hormone (MCH), a cyclic peptide that regulates a variety of functions in the mammalian brain, in particular feeding behaviour, and it is demonstrated that nanomolar concentrations of MCH strongly activate SLC-1-related pathways through Gαi and/or Gαq proteins.
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Distribution of dynorphin and enkephalin peptides in the rat brain.
TL;DR: From these neuroanatomical data, it appears that the dynorphin and enkephalin peptides are strategically located in brain regions that regulate extrapyramidal motor function, cardiovascular and water balance systems, eating, sensory processing, and pain perception.
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The Dynamic Effects of Nicotine on the Developing Brain
TL;DR: Evidence is presented that nicotine interferes with catecholamine and brainstem autonomic nuclei development during the prenatal period of the rodent, alters the neocortex, hippocampus, and cerebellum during the early postnatal period (third trimester of the human), and influences limbic system and late monoamine maturation during adolescence.