F
Francesca Bartoli-Leonard
Researcher at Brigham and Women's Hospital
Publications - 16
Citations - 182
Francesca Bartoli-Leonard is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 3, co-authored 8 publications receiving 79 citations. Previous affiliations of Francesca Bartoli-Leonard include Manchester Metropolitan University.
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Journal ArticleDOI
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling
Francesca Bartoli-Leonard,Fiona L. Wilkinson,Andrew Schiro,F. Serracino Inglott,Michelle Alexander,Ria Weston +5 more
TL;DR: The findings demonstrate the key role that SIRT1 plays in preventing calcification in a diabetic environment, through the inhibition of RUNX2 and senescence pathways, suggesting a downregulation of Sirt1 may be responsible for perpetuating vascular calcification within the diabetic environment.
Journal ArticleDOI
Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification.
Francesca Bartoli-Leonard,Fiona L. Wilkinson,Andrew Schiro,Ferdinand Serracino Inglott,M. Yvonne Alexander,Ria Weston +5 more
TL;DR: DNA damage-induced calcification is accelerated within a diabetic environment and can be attenuated in vitro by SIRT1 activation, which occurs through enhancement of the MRN repair complex within vSMCs and has therapeutic potential within the diabetic patient.
Journal ArticleDOI
The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification.
Francesca Bartoli-Leonard,Fiona L. Wilkinson,Alex Langford-Smith,Michelle Alexander,Ria Weston +4 more
TL;DR: The current concepts of pathological soft tissue mineralization are described, with a focus on the contribution of SIRT1 as a regulator of Wnt signaling and its targets, discussing SIRT 1 as a potential target for manipulation and therapy.
Journal ArticleDOI
Innate and adaptive immunity: the understudied driving force of heart valve disease.
TL;DR: The role of the immune system in the progression of valve stenosis is investigated in this paper, showing that 15% of cells evolve from haemopoietic origin, and this number greatly expands following inflammation, as macrophages, T lymphocytes, B lymphocytes and innate immune cells infiltrate the valve, promoting further inflammation.
Journal ArticleDOI
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Julius L. Decano,Yukio Iwamoto,Shinji Goto,Janey Y. Lee,Joan T. Matamalas,Arda Halu,Mark C. Blaser,Lang H Lee,Brett Pieper,Sarvesh Chelvanambi,Jessica Silva-Nicolau,Francesca Bartoli-Leonard,Hideyuki Higashi,Haruki Shibata,Payal Vyas,Jianguo Wang,Elena V. Gostjeva,Simon C. Body,Sasha A Singh,Masanori Aikawa,Elena Aikawa +20 more
TL;DR: In this paper , a disease-driver population (DDP) within valvular interstitial cells (VICs) was identified through stepwise single-cell analysis, phenotype-guided omic profiling, and network-based analysis, and the DDP fingerprint was characterized as CD44highCD29+CD59+CD73+CD45low.