F
Fiona L. Wilkinson
Researcher at Manchester Metropolitan University
Publications - 65
Citations - 2577
Fiona L. Wilkinson is an academic researcher from Manchester Metropolitan University. The author has contributed to research in topics: Endothelial dysfunction & Calcification. The author has an hindex of 26, co-authored 65 publications receiving 2052 citations. Previous affiliations of Fiona L. Wilkinson include Manchester Academic Health Science Centre & Wellcome Trust Centre for Cell-Matrix Research.
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Journal ArticleDOI
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.
Masih-ul Alam,John Paul Kirton,Fiona L. Wilkinson,Fiona L. Wilkinson,Emily Towers,Smeeta Sinha,Mansour Rouhi,Thomas Neill Vizard,Andrew P. Sage,David Martin,Donald T. Ward,Marie Yvonne Alexander,Daniela Riccardi,Ann E. Canfield,Ann E. Canfield +14 more
TL;DR: The results demonstrate that VSMCs express a functional CaR and a reduction in CaR expression is associated with increased mineralization in vivo and in vitro, and suggest that calcimimetics may inhibit the development of VC in CKD patients.
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The Role of Nrf2 in Cardiovascular Function and Disease
TL;DR: The current status of Nrf2 and related signaling in cardiovascular disease and its relevance to current and potential treatment strategies are reviewed.
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Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB
Fiona L. Wilkinson,Rebecca J. Holley,Kia J. Langford-Smith,Soumya Badrinath,Aiyin Liao,Alex Langford-Smith,Jonathan D. Cooper,Simon Jones,J. Ed Wraith,Rob Wynn,Catherine L.R. Merry,Brian W. Bigger +11 more
TL;DR: It is suggested that MPSIIIA and IIIB have more pronounced neuropathology than MPSI, yet all are still progressive, at least in some aspects of neuro Pathology, from 4–9 months.
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Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease
Marcelina Malinowska,Marcelina Malinowska,Fiona L. Wilkinson,Kia J. Langford-Smith,Alex Langford-Smith,Jillian R. Brown,Brett E. Crawford,Marie T. Vanier,Grzegorz Grynkiewicz,Rob Wynn,J. Ed Wraith,Grzegorz Węgrzyn,Brian W. Bigger,Brian W. Bigger +13 more
TL;DR: Genistein may prove useful as a substrate reduction agent to delay clinical onset of MPSIIIB and, due to its multimodal action, may provide a treatment adjunct for several other neurodegenerative metabolic diseases.
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Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.
Yvonne Alexander,Elena Osto,Elena Osto,Arno Schmidt-Trucksäss,Michael Shechter,Michael Shechter,Danijela Trifunovic,Dirk J. Duncker,Victor Aboyans,Magnus Bäck,Magnus Bäck,Lina Badimon,Francesco Cosentino,Marco De Carlo,Maria Dorobantu,David G. Harrison,Tomasz J. Guzik,Tomasz J. Guzik,Imo E. Hoefer,Paul Morris,Giuseppe Danilo Norata,Rosa Suades,Stefano Taddei,Gemma Vilahur,Johannes Waltenberger,Christian Weber,Fiona L. Wilkinson,Marie-Luce Bochaton-Piallat,Paul C. Evans +28 more
TL;DR: It is proposed that a consensus methodology for FMD is universally adopted to minimize technical variation between studies, and that reference FMD values are established for different populations of healthy individuals and patient groups.