F
Francesca Bertolini
Researcher at Technical University of Denmark
Publications - 114
Citations - 1680
Francesca Bertolini is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Population & Asthma. The author has an hindex of 18, co-authored 101 publications receiving 1090 citations. Previous affiliations of Francesca Bertolini include Katholieke Universiteit Leuven & University of Bologna.
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Journal ArticleDOI
Signatures of selection and environmental adaptation across the goat genome post-domestication
Francesca Bertolini,Francesca Bertolini,Bertrand Servin,Andrea Talenti,Estelle Rochat,Eui-Soo Kim,Claire Oget,Isabelle Palhiere,Alessandra Crisà,Gennaro Catillo,Roberto Steri,Marcel Amills,Licia Colli,Gabriele Marras,Marco Milanesi,Marco Milanesi,Ezequiel L. Nicolazzi,Benjamin D. Rosen,Curtis P. Van Tassell,Bernt Guldbrandtsen,Tad S. Sonstegard,Gwenola Tosser-Klopp,Alessandra Stella,Max F. Rothschild,Stéphane Joost,Paola Crepaldi +25 more
TL;DR: These analyses of signatures of selection provide a comprehensive first picture of the global domestication process and adaptation of goat breeds and highlight possible genes that may have contributed to the differentiation of this species worldwide.
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Genome-wide SNP profiling of worldwide goat populations reveals strong partitioning of diversity and highlights post-domestication migration routes
Licia Colli,Marco Milanesi,Marco Milanesi,Andrea Talenti,Francesca Bertolini,Francesca Bertolini,Minhui Chen,Minhui Chen,Alessandra Crisà,Kevin G. Daly,Marcello Del Corvo,Bernt Guldbrandtsen,Johannes A. Lenstra,Benjamin D. Rosen,Elia Vajana,Elia Vajana,Gennaro Catillo,Stéphane Joost,Ezequiel L. Nicolazzi,Estelle Rochat,Max F. Rothschild,Bertrand Servin,Tad S. Sonstegard,Roberto Steri,Curtis P. Van Tassell,Paolo Ajmone-Marsan,Paola Crepaldi,Alessandra Stella +27 more
TL;DR: This work analysed genome-wide 50 K single nucleotide polymorphism (SNP) data from 144 populations to describe the global patterns of molecular variation, compare them to those observed in other livestock species, and identify the drivers that led to the current distribution of goats.
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Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma.
Michela Bullone,Vitina Carriero,Francesca Bertolini,Anna Folino,Alessandro Mannelli,Antonino Di Stefano,Isabella Gnemmi,Roberto Torchio,Fabio Luigi Massimo Ricciardolo +8 more
TL;DR: New evidence is provided linking the presence of high bronchial neutrophilia in asthma to an adaptive immune response associated with allergy (IgE) and IL-17/22 cytokine expression and may discriminate a new endotype of asthma.
Journal ArticleDOI
A next generation semiconductor based sequencing approach for the identification of meat species in DNA mixtures.
Francesca Bertolini,Marco Ciro Ghionda,Enrico D'Alessandro,Claudia Geraci,Vincenzo Chiofalo,Luca Fontanesi +5 more
TL;DR: The next generation semiconductor based sequencing technology (Ion Torrent Personal Genome Machine) is evaluated for the identification of DNA from meat species as well as from human and rat in DNA mixtures through the sequencing of PCR products obtained from different couples of universal primers.
Journal ArticleDOI
Genome-wide patterns of homozygosity provide clues about the population history and adaptation of goats
Francesca Bertolini,Tainã Figueiredo Cardoso,Gabriele Marras,Ezequiel L. Nicolazzi,Max F. Rothschild,Marcel Amills +5 more
TL;DR: The existence of three ROH hotspots that co-localize with signatures of selection demonstrates that selection has also played an important role in increasing the homozygosity of specific regions in the goat genome.