F
Francesca Santoro
Researcher at Istituto Italiano di Tecnologia
Publications - 73
Citations - 1907
Francesca Santoro is an academic researcher from Istituto Italiano di Tecnologia. The author has contributed to research in topics: Computer science & Bioelectronics. The author has an hindex of 18, co-authored 53 publications receiving 1149 citations. Previous affiliations of Francesca Santoro include University of Naples Federico II & Stanford University.
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Journal ArticleDOI
Nanoscale manipulation of membrane curvature for probing endocytosis in live cells.
Wenting Zhao,Lindsey Hanson,Lindsey Hanson,Hsin-Ya Lou,Matthew Akamatsu,Praveen D. Chowdary,Francesca Santoro,Jessica R. Marks,Alexandre Grassart,Alexandre Grassart,David G. Drubin,Yi Cui,Yi Cui,Bianxiao Cui +13 more
TL;DR: Nanostructured substrates constitute a novel tool for investigating curvature-dependent processes in live cells and are found that the positively curved membranes are CME hotspots, and that key CME proteins, clathrin and dynamin, show a strong preference towards positive membrane curvatures with a radius <200 nm.
Journal ArticleDOI
A biohybrid synapse with neurotransmitter-mediated plasticity
Scott T. Keene,Claudia Lubrano,Setareh Kazemzadeh,Armantas Melianas,Yaakov Tuchman,Giuseppina Polino,Paola Scognamiglio,Lucio Cinà,Alberto Salleo,Yoeri van de Burgt,Francesca Santoro +10 more
TL;DR: A cell culture interfacing an organic neuromorphic device in a microfluidic system reversibly modifies the device synaptic weight through chemical reactions mediated by the release of dopamine, a neurotransmitter used in biological synapses, paving the way towards combining artificial neuromorphic systems with biological neural networks.
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Revealing the Cell-Material Interface with Nanometer Resolution by Focused Ion Beam/Scanning Electron Microscopy
Francesca Santoro,Wenting Zhao,Lydia-Marie Joubert,Liting Duan,Jan Schnitker,Yoeri van de Burgt,Hsin-Ya Lou,Bofei Liu,Alberto Salleo,Lifeng Cui,Yi Cui,Bianxiao Cui +11 more
TL;DR: By examining how cell membranes interact with topographical features such as nanoscale protrusions or invaginations, it is discovered that the cell membrane readily deforms inward and wraps around protruding structures, but hardly deforms outward to contour invaginating structures.
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Membrane curvature underlies actin reorganization in response to nanoscale surface topography
Hsin-Ya Lou,Wenting Zhao,Xiao Li,Liting Duan,Alexander S. Powers,Matthew Akamatsu,Francesca Santoro,Allister F. McGuire,Yi Cui,David G. Drubin,Bianxiao Cui +10 more
TL;DR: This study illustrates that membrane curvatures induced by nanoscale surface topography can serve as a direct biochemical signal to activate curvature-sensing protein and regulate actin polymerization and mechanotransduction in the intracellular space.
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Interfacing Electrogenic Cells with 3D Nanoelectrodes: Position, Shape, and Size Matter
Francesca Santoro,Sabyasachi Dasgupta,Jan Schnitker,Thorsten Auth,Elmar Neumann,G. Panaitov,Gerhard Gompper,Andreas Offenhäusser +7 more
TL;DR: A profound study of the cell interface with two widely used nanostructure types, cylindrical pillars with and without a cap, and the combination of electron microscopy investigations with a theoretical membrane deformation model allows us to predict the optimal shape and dimensions of 3D nanostructures for cell-chip coupling.