F
Francesco Orzi
Researcher at Sapienza University of Rome
Publications - 115
Citations - 4517
Francesco Orzi is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Nucleus accumbens & Dementia. The author has an hindex of 29, co-authored 115 publications receiving 4054 citations. Previous affiliations of Francesco Orzi include United States Public Health Service & National Institutes of Health.
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Journal ArticleDOI
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
TL;DR: It is reported that intravenous nicotine in the rat, at doses known to maintain self-administration, stimulates local energy metabolism, as measured by 2-deoxyglucose autoradiography, and dopamine transmission, as estimated by brain microdialysis, in the shell of the nucleus accumbens.
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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
Christian Chiamulera,Mark P. Epping-Jordan,Alessandro Zocchi,Clara Marcon,Cécilia Cottiny,Stefano Tacconi,Mauro Corsi,Francesco Orzi,François Conquet +8 more
TL;DR: It is shown that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type mice.
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The effects of 5-minute ischemia in Mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes.
TL;DR: Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in Mongolian gerbils following 5 min cerebral ischemia, producing by bilateral clamping of the common carotid arteries.
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Riluzole in patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial
Silvia Romano,Giulia Coarelli,Christian Marcotulli,Luca Leonardi,Francesca Piccolo,Maria Spadaro,Marina Frontali,Michela Ferraldeschi,Maria Chiara Vulpiani,Federica Ponzelli,Marco Salvetti,Francesco Orzi,Antonio Petrucci,Nicola Vanacore,Carlo Casali,Giovanni Ristori +15 more
TL;DR: The findings lend support to the idea that riluzole could be a treatment for cerebellar ataxia, and longer studies and disease-specific trials are needed to confirm whether these findings can be applied in clinical practice.
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Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
Mara D'Onofrio,L. Cuomo,Giuseppe Battaglia,Richard Teke Ngomba,Marianna Storto,A.E. Kingston,Francesco Orzi,A De Blasi,P. Di Iorio,Ferdinando Nicoletti,Valeria Bruno +10 more
TL;DR: Results suggest that activation of glial mGlu2/3 receptors induces neuroprotection through the activation of the MAPK and PI‐3‐K pathways leading to the induction of TGF‐β.