F
Francesco Resta
Researcher at University of Florence
Publications - 23
Citations - 410
Francesco Resta is an academic researcher from University of Florence. The author has contributed to research in topics: Optogenetics & AMPA receptor. The author has an hindex of 11, co-authored 23 publications receiving 291 citations. Previous affiliations of Francesco Resta include European Laboratory for Non-Linear Spectroscopy.
Papers
More filters
Journal ArticleDOI
Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation.
TL;DR: GPR35 agonists, by reducing adenylate cyclase activity and inhibiting Ih in DRG neurons may represent a promising new group of analgesic drugs, and are tested in an in vivo model of PGE2-induced thermal hyperalgesia.
Journal ArticleDOI
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy.
Francesco Resta,Laura Micheli,Annunziatina Laurino,Valentina Spinelli,Tommaso Mello,Laura Sartiani,L. Di Cesare Mannelli,Elisabetta Cerbai,Carla Ghelardini,Maria Novella Romanelli,Guido Mannaioni,Alessio Masi +11 more
TL;DR: This study strengthens the evidence for a disease‐specific role ofHCN1 in CIPN, and proposes HCN1‐selective inhibitors as new‐generation pain medications with the desired efficacy and safety profile.
Journal ArticleDOI
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites
Daniela Buonvicino,Francesca Mazzola,Federica Zamporlini,Francesco Resta,Giuseppe Antonio Ranieri,Emidio Camaioni,Mirko Muzzi,Riccardo Zecchi,Giuseppe Pieraccini,Christian Dölle,Massimo Calamante,Gianluca Bartolucci,Mathias Ziegler,Barbara Stecca,Nadia Raffaelli,Alberto Chiarugi +15 more
TL;DR: The identification of Vacor as a substrate metabolized by the consecutive action of NAMPT and NMNAT2 into the NAD analog Vacor adenine dinucleotide (VAD) causes unprecedented rapid NAD depletion, glycolytic block, energy failure, and necrotic death of NM NAT2-proficient cancer cells.
Journal ArticleDOI
PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2 +-permeable AMPA receptors
Elisabetta Gerace,Alessio Masi,Francesco Resta,Roberta Felici,Elisa Landucci,Tommaso Mello,Domenico E. Pellegrini-Giampietro,Guido Mannaioni,F. Moroni +8 more
TL;DR: The results show that activation of the nuclear enzyme PARP-1 may change the expression of membrane proteins and Ca(2+) permeability of AMPA channels, thus affecting the function and survival of CA1 pyramidal cells.
Journal ArticleDOI
Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain.
L. Dini,Martina Del Lungo,Francesco Resta,Michele Melchiorre,Valentina Spinelli,Leonardo Di Cesare Mannelli,Carla Ghelardini,Annunziatina Laurino,Laura Sartiani,Raffaele Coppini,Guido Mannaioni,Elisabetta Cerbai,Maria Novella Romanelli +12 more
TL;DR: Selective blockade of HCN1/HCN2 channels, over HCN4 isoform, was able to modulate electrophysiological properties of DRG neurons similarly to that reported for classical Ih blockers, ivabradine, resulting in a pain-relieving activity.