G
Gianluca Bartolucci
Researcher at University of Florence
Publications - 143
Citations - 2811
Gianluca Bartolucci is an academic researcher from University of Florence. The author has contributed to research in topics: Medicine & Carbonic anhydrase. The author has an hindex of 26, co-authored 117 publications receiving 2103 citations. Previous affiliations of Gianluca Bartolucci include ARPA-E & International Military Sports Council.
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Journal ArticleDOI
Sponge-associated microbial Antarctic communities exhibiting antimicrobial activity against Burkholderia cepacia complex bacteria.
Maria Cristiana Papaleo,Marco Fondi,Isabel Maida,Elena Perrin,Angelina Lo Giudice,Luigi Michaud,Santina Mangano,Gianluca Bartolucci,Riccardo Romoli,Renato Fani +9 more
TL;DR: The whole body of data obtained in this work indicates that sponge-associated bacteria represent an untapped source for the identification of new antimicrobial compounds and are paving the way for the discovery of new drugs that can be efficiently and successfully used for the treatment of CF infections.
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Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.
Silvia Bua,Lorenzo Di Cesare Mannelli,Daniela Vullo,Carla Ghelardini,Gianluca Bartolucci,Andrea Scozzafava,Claudiu T. Supuran,Fabrizio Carta +7 more
TL;DR: A series of hybrid compounds incorporating 6- and 7-substituted coumarins derivatized with clinically used NSAIDs as agents for the management of rheumatoid arthritis showed potent and persistent antihyperalgesic effect up to 60 min after administration.
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Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression.
Gustavo Ayala,Matteo Morello,Matteo Morello,Anna Frolov,Sungyong You,Rile Li,Fabiana Rosati,Gianluca Bartolucci,Giovanna Danza,Rosalyn M. Adam,Timothy C. Thompson,Michael P. Lisanti,Michael R. Freeman,Michael R. Freeman,Michael R. Freeman,Dolores Di Vizio,Dolores Di Vizio +16 more
TL;DR: Loss of Cav‐1 in the tumour microenvironment contributes to the metastatic behaviour of tumour cells by a mechanism that involves up‐regulation of TGF‐β1 and SNCG through Akt activation, and intracrine production of androgens, a process relevant to castration resistance, may occur in the stroma.
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Dominulin A and B : Two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap
Stefano Turillazzi,Guido Mastrobuoni,Francesca Romana Dani,Gloriano Moneti,Giuseppe Pieraccini,Giancarlo la Marca,Gianluca Bartolucci,Brunella Perito,Duccio Lambardi,Vanni Cavallini,Leonardo Dapporto +10 more
TL;DR: Two new antibacterial peptides, denominated as Dominulin A and B, have been found on the cuticle and in the venom of females of the social paper wasp Polistes dominulus, suggesting their classification in the mastoparans, a class of peptides found in the Venom of other Aculeate hymenoptera.
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Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.
Raffaele Coppini,Luca Mazzoni,Cecilia Ferrantini,Francesca Gentile,Josè Manuel Pioner,Annunziatina Laurino,Lorenzo Santini,V. Bargelli,Matteo Rotellini,Gianluca Bartolucci,Claudia Crocini,Leonardo Sacconi,Chiara Tesi,Luiz Belardinelli,Jil C. Tardiff,Alessandro Mugelli,Iacopo Olivotto,Elisabetta Cerbai,Corrado Poggesi +18 more
TL;DR: Owing to the sustained reduction of intracellular Ca2+ and calmodulin kinase activity, ranolazine prevented the development of morphological and functional cardiac phenotype in mice carrying a clinically relevant HCM-related mutation.