Francesco Talotta

TL;DR: It is shown that the miRNA miR-21, which represents the most frequently upregulated oncomir in solid tumors, is induced by AP-1 in response to RAS, and that the tumor suppressors PTEN and PDCD4 are downregulated by RAS in anAP-1- and miR -21-dependent fashion.

TL;DR: It is shown that in a small cohort of NSCLC patients, representative of all four stages of lung cancer, miR-340 expression inversely correlates with clinical staging, thus suggesting that miR -340 downregulation contributes to the disease progression.

TL;DR: This work focuses on the Fra-1 protein in tumorigenesis, which offers an illustrative example of this helter-skelter voyage of the AP-1 transcription factor complex.

TL;DR: A novel role of the PREP1 homeoprotein in the control of the TGF-β pathway, EMT, and metastasis in NSCLC is points to a novel, promising therapeutic target in non-small cell lung cancer.

TL;DR: It is reported that uPAR‐lacking mice display increased BMD, increased osteogenic potential of osteoblasts, decreased osteoclasts formation, and altered cytoskeletal reorganization in mature osteoclast.