Ylermi Soini

TL;DR: It is shown that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.

TL;DR: The authors showed that a frameshift mutation, c.1592delT, is present at significantly elevated frequency in familial breast cancer cases compared with ancestry-matched population controls, and that the truncated protein caused by this mutation retained little BRCA2-binding capacity and was deficient in homologous recombination and crosslink repair.

TL;DR: The present review aims to clarify the significance of oxidative stress and the role of cell redox state modulating systems in human malignancies in light of the current literature.

TL;DR: CA IX was proved to be an independent prognostic indicator in oligodendroglial brain tumors, and it also correlates reversely with cell proliferation, which could serve as a target molecule for anticancer treatments.

TL;DR: The molecular mechanisms of apoptosis are given, as extracted from the literature and based on the currently used methods to determine the number of apoptotic cells in tumor samples and their limitations, and the apoptotic index as a prognostic marker is reviewed.