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Francine Acher
Researcher at Paris Descartes University
Publications - 139
Citations - 4691
Francine Acher is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Metabotropic glutamate receptor & Agonist. The author has an hindex of 37, co-authored 135 publications receiving 4327 citations. Previous affiliations of Francine Acher include University of Paris & University of Montpellier.
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Journal ArticleDOI
The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.
Jean-Philippe Pin,Francine Acher +1 more
TL;DR: The present review article focuses on the specific structural features of these receptors and highlights the various possibilities these offer for drug development.
Journal ArticleDOI
The Heptahelical Domain of GABAB2 Is Activated Directly by CGP7930, a Positive Allosteric Modulator of the GABAB Receptor *
Virginie Binet,Carole Brajon,Laurent Le Corre,Francine Acher,Jean-Philippe Pin,Laurent Prézeau +5 more
TL;DR: The mechanism of action of CGP7930, a compound described as a positive allosteric regulator of the GABAB receptor, was explored and it was demonstrated that the HD of GABAB2 behaves similar to a rhodopsin-like receptor, because it can reach the cell surface alone, can couple to G-protein, and be activated by agonists.
Journal ArticleDOI
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors
Cyril Goudet,Florence Gaven,Julie Kniazeff,Claire Vol,Jiang-Feng Liu,Martin Cohen-Gonsaud,Francine Acher,Laurent Prézeau,Jean-Philippe Pin +8 more
TL;DR: It is shown that the HD of metabotropic glutamate receptor 5 (mGlu5) displays the same agonist-independent constitutive activity as the wild-type receptor, and illustrates that, like rhodopsin-like receptors, theHD of mGluRs can constitutively couple to G proteins and be negatively and positively regulated by ligands.
Journal ArticleDOI
New perspectives for the development of selective metabotropic glutamate receptor ligands
TL;DR: The metabotropic glutamate receptors are GTP-binding-protein (G-protein) coupled receptors that play important roles in regulating the activity of many synapses in the central nervous system.
Journal ArticleDOI
Comparative effect of l-CCG-I, DCG-IV and γ-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes
Isabelle Brabet,Marie-Laure Parmentier,Cyril De Colle,Joël Bockaert,Francine Acher,Jean-Philippe Pin +5 more
TL;DR: It is shown here that L-CCG-I is a general mGlu receptor agonist activating all cloned receptors, and it is confirmed that DCG-IV, which corresponds to L- CCG- I with an additional carboxylic group, is a selective group-II agonist.