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Isabelle Brabet
Researcher at Centre national de la recherche scientifique
Publications - 31
Citations - 2451
Isabelle Brabet is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Metabotropic glutamate receptor & Metabotropic receptor. The author has an hindex of 23, co-authored 31 publications receiving 2368 citations. Previous affiliations of Isabelle Brabet include University of Montpellier & French Institute of Health and Medical Research.
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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
Laura Albizu,Martin Cottet,Martin Cottet,Martin Cottet,Michaela Kralikova,Stoytcho Stoev,René Seyer,René Seyer,René Seyer,Isabelle Brabet,Isabelle Brabet,Isabelle Brabet,Thomas Roux,Herve Bazin,Emmanuel Bourrier,Laurent Lamarque,Christophe Breton,Marie-Laure Rives,Amy Hauck Newman,Jonathan A. Javitch,Eric Trinquet,Maurice Manning,Jean-Philippe Pin,Jean-Philippe Pin,Jean-Philippe Pin,Bernard Mouillac,Bernard Mouillac,Bernard Mouillac,Thierry Durroux,Thierry Durroux,Thierry Durroux +30 more
TL;DR: A time-resolved FRET strategy based on receptor labeling with selective fluorescent ligands was developed and applied to native tissues and succeeded in demonstrating the presence of oxytocin receptor dimers and/or oligomers in mammary gland.
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Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
TL;DR: A splice variant of mGluR5 is characterized which contains a 32 amino acid fragment inserted in the cytoplasmic tail, 50 residues after the 7th transmembrane domain, which indicates that the long C-terminal intracellular domain present only in mGlam glutamate receptors, although not well conserved, is likely to be involved in the specific functional properties of these receptors.
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Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses
TL;DR: It is suggested that the apparent potency of phenylglycine antagonists depends on the agonist used to activate these receptors and the compound was found to potently and competitively antagonize the effect of 1S,3R-ACPD.
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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Fiona Y Carroll,Andreas Stolle,Philip M Beart,Arnd Voerste,Isabelle Brabet,Frank Mauler,Cécile Joly,Horst Antonicek,Joël Bockaert,Thomas Müller,Jean-Philippe Pin,Laurent Prézeau +11 more
TL;DR: BAY36-7620 will be useful to further delineate the functional importance of the mGlu1 receptor, including its putative agonist-independent activity, andTransmembrane helices 4 to 7 are shown to play a critical role in the selectivity of BAY36- 7620.
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Comparative effect of l-CCG-I, DCG-IV and γ-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes
Isabelle Brabet,Marie-Laure Parmentier,Cyril De Colle,Joël Bockaert,Francine Acher,Jean-Philippe Pin +5 more
TL;DR: It is shown here that L-CCG-I is a general mGlu receptor agonist activating all cloned receptors, and it is confirmed that DCG-IV, which corresponds to L- CCG- I with an additional carboxylic group, is a selective group-II agonist.