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Francisca E. Reyes-Turcu
Researcher at Emory University
Publications - 14
Citations - 3432
Francisca E. Reyes-Turcu is an academic researcher from Emory University. The author has contributed to research in topics: Deubiquitinating enzyme & Ubiquitin. The author has an hindex of 13, co-authored 14 publications receiving 3117 citations. Previous affiliations of Francisca E. Reyes-Turcu include National Institutes of Health.
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Journal ArticleDOI
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
TL;DR: A review of recent studies of the regulation of DUB activity and their roles in various cellular processes can be found in this paper, where the authors discuss ubiquitin-specific DUBs and some of the generalizations emerging from recent studies.
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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
David Komander,David Komander,Francisca E. Reyes-Turcu,Julien D.F. Licchesi,Peter Odenwaelder,Keith D. Wilkinson,David Barford +6 more
TL;DR: Crystallized Lys 63‐linked and linear ubiquitin dimers are revealed, revealing that both adopt equivalent open conformations, forming no contacts between Ubiquitin molecules and thereby differing significantly from Lys 48‐linked ubiquitIn chains.
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The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.
Francisca E. Reyes-Turcu,John R. Horton,James E. Mullally,Annie Heroux,Xiaodong Cheng,Keith D. Wilkinson +5 more
TL;DR: The crystal structures of the zinc-finger ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with ubiquitIn are reported, suggesting that binding the Ubiquitin C terminus may be necessary for the function of other proteins.
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RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation
Martin Zofall,Soichiro Yamanaka,Francisca E. Reyes-Turcu,Ke Zhang,Chanan Rubin,Shiv I. S. Grewal +5 more
TL;DR: These analyses uncover unexpected regulatory roles for mRNA-processing factors that assemble dynamic heterochromatin to modulate gene expression and show that their formation at meiotic genes requires factors that eliminate meiotic messenger RNAs (mRNAs) during vegetative growth.
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Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.
Nathan N. Lee,Venkata R. Chalamcharla,Francisca E. Reyes-Turcu,Sameet Mehta,Martin Zofall,Vanivilasini Balachandran,Jothy Dhakshnamoorthy,Nitika Taneja,Soichiro Yamanaka,Ming Zhou,Shiv I. S. Grewal +10 more
TL;DR: A nuclear RNA-processing network in fission yeast with a core module comprising the Mtr4-like protein, Mtl1, and the zinc-finger protein, Red1 is described, revealing unique cellular strategies for recognizing regulatory RNAs and coordinating their functions in response to developmental and environmental cues.