Francisco Donoso

TL;DR: It is shown that rejuvenation of the gut microbiome by fecal microbiota transplantation from young mice reverses aging-induced deficits in the hippocampal immune system, metabolome and transcriptome, and rescues selective cognitive deficits.

TL;DR: The preclinical and clinical studies available on phospholipid-based strategies for improved brain health across the lifespan are summarized and the hypothesized direct and indirect mechanisms of action of these lipid-based interventions which may be used to promote resilience to stress and improve age-related cognitive decline in vulnerable populations are summarized.

TL;DR: It is suggested that naturally-derived polyphenols exert antidepressant-like effects in MS rats, which mechanisms could be potentially mediated by HPA regulation, BDNF levels rescue and modulation of the microbiota-gut-brain axis.

TL;DR: The role of the microbiota-gut-brain axis as a potential mediator for the adjunctive therapies for depression through inflammatory mechanisms is discussed and the current information about the strategies to alleviate depression is reviewed.

TL;DR: The results of this study provide a further advancement into the understanding of some of the complex systems within which nutraceuticals and pharmaceuticals effect the microbiota-gut-brain axis.