Marcus Boehme

TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

TL;DR: Administration of SCFAs to mice undergoing psychosocial stress alleviates enduring alterations in anhedonia and heightened stress‐responsiveness, as well as stress‐induced increases in intestinal permeability, informing the development of microbiota‐targeted therapies for stress‐related disorders.

TL;DR: It is shown that rejuvenation of the gut microbiome by fecal microbiota transplantation from young mice reverses aging-induced deficits in the hippocampal immune system, metabolome and transcriptome, and rescues selective cognitive deficits.

TL;DR: Targeting the gut microbiome with prebiotics can modulate the peripheral immune response and alter neuroinflammation in middle age, highlighting a novel strategy for the amelioration of age-related neuroinflammatory pathologies and brain function.

TL;DR: Evidence is provided that a diet supplemented with ω-3 PUFAs and vitamin A prevents deleterious cognitive impairment and shift of microbiota composition induced by social instability stress during adolescence, and that amelioration is maintained through adulthood, suggesting that a healthy diet may have long-lasting beneficial effects and help fight off neurodegenerative diseases.