Journal ArticleDOI
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
Deborah R. Gill,Stephen C. Hyde,Christopher F. Higgins,Miguel A. Valverde,G. M. Mintenig,Francisco V. Sepúlveda +5 more
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TLDR
Data provided provide further evidence that P-glycoprotein is bifunctional with both transport and channel activities and implications for the design of chemotherapeutic drugs and for the function of the related cystic fibrosis gene product, CFTR are discussed.About:
This article is published in Cell.The article was published on 1992-10-02. It has received 328 citations till now. The article focuses on the topics: Chloride channel & Membrane transport.read more
Citations
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Journal ArticleDOI
ABC Transporters: From Microorganisms to Man
TL;DR: This chapter discusses thebuilding blocks of the Transmembrane Complex, and some of the properties of these blocks have changed since the publication of the original manuscript in 1993.
Journal ArticleDOI
Mammalian ABC Transporters in Health and Disease
Piet Borst,R.P.J. Oude Elferink +1 more
TL;DR: This work focuses on three topics: ABC transporters transporting drugs (xenotoxins) and drug conjugates, and a rapidly increasing number of ABC Transporters found to play a role in lipid transport.
Journal ArticleDOI
Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
J. J. M. Smit,A.H. Schinkel,R.P.J. Oude Elferink,A.K. Groen,Els Wagenaar,L. Van Deemter,C. A. A. M. Mol,Roel Ottenhoff,N. M. T. Van Der Lugt,M van Roon,M. A. Van Der Valk,G.J.A. Offerhaus,A Berns,Piet Borst +13 more
TL;DR: It is concluded that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholIPid flippase.
Journal ArticleDOI
Molecular Structure and Physiological Function of Chloride Channels
TL;DR: The loss of distinct Cl- channels leads to an impairment of transepithelial transport in cystic fibrosis and Bartter's syndrome, to increased muscle excitability in myotonia congenita, to reduced endosomal acidification and impaired endocytosis in Dent's disease, and to impaired extracellular acidification by osteoclasts and osteopetrosis.
Journal ArticleDOI
CFTR Is a Conductance Regulator as well as a Chloride Channel
TL;DR: This review focuses on a plethora of studies showing that CFTR also regulates other ion channel proteins, and it is the hope of the authors that the reader will take with him or her the message thatCFTR is a conductance regulator as well as a Cl- channel.
References
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Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Journal ArticleDOI
ABC Transporters: From Microorganisms to Man
TL;DR: This chapter discusses thebuilding blocks of the Transmembrane Complex, and some of the properties of these blocks have changed since the publication of the original manuscript in 1993.
Journal ArticleDOI
The biochemistry of P-glycoprotein-mediated multidrug resistance.
Jane A. Endicott,Ling +1 more
Journal ArticleDOI
The P-loop--a common motif in ATP- and GTP-binding proteins.
TL;DR: Current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.
Journal ArticleDOI
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport.
Stephen C. Hyde,Paul Emsley,Michael J. Hartshorn,Michael M. Mimmack,Uzi Gileadi,Stephen R. Pearce,Stephen R. Pearce,Maurice P. Gallagher,Maurice P. Gallagher,Deborah R. Gill,Roderick E. Hubbard,Christopher F. Higgins +11 more
TL;DR: A tertiary structure model of the ATP-binding cassettes characteristic of this class of transport system is presented, based on similarities between the predicted secondary structures of members of this family and the previously determined structure of adenylate kinase.
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Biochemistry of multidrug resistance mediated by the multidrug transporter.
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