Franco Borzio

TL;DR: Cirrhotic patients infected with HCV type 1b carry a significantly higher risk of developing HCC than patients infected by other HCV types, and the latter may require a less intensive clinical surveillance for the early detection of neoplasia.

TL;DR: The evaluation of this large series of HCC patients allowed us to confirm the low sensitivity of AFP in the diagnosis of H CC and its prognostic value, albeit limited, being tumor size, female sex, Child-Pugh score, and TNM staging independent predictors.

TL;DR: Semiannual surveillance increases the detection rate of very early hepatocellular carcinomas and reduces the number of advanced tumors as compared to the annual program, which translates into a greater applicability of effective treatments and into a better prognosis.

TL;DR: The results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.

TL;DR: Macronodules characterize a cirrhotic subpopulation with high risk of hepatocellular carcinoma; HGDN and LCC are strong predictors of malignant transformation; subjects with simultaneous presence of both these two conditions are at highest risk of cancer development.