E
Enrico Silini
Researcher at University of Pavia
Publications - 61
Citations - 3230
Enrico Silini is an academic researcher from University of Pavia. The author has contributed to research in topics: Hepatitis C virus & Liver disease. The author has an hindex of 30, co-authored 61 publications receiving 3191 citations. Previous affiliations of Enrico Silini include University of Milan.
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Journal ArticleDOI
Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: a prospective study
Saving Bruno,Enrico Silini,Andrea Crosignani,Franco Borzio,Gioacchino Leandro,Fulvia Bono,M. Asti,Sonia Rossi,Alberto Larghi,Antonella Cerino,Mauro Podda,Mario U. Mondelli +11 more
TL;DR: Cirrhotic patients infected with HCV type 1b carry a significantly higher risk of developing HCC than patients infected by other HCV types, and the latter may require a less intensive clinical surveillance for the early detection of neoplasia.
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Clinical significance of hepatitis C virus genotypes
Mario U. Mondelli,Enrico Silini +1 more
TL;DR: In this article, a general consensus has been reached on the worldwide epidemiology and distribution of hepatitis C virus (HCV) types in certain risk categories (i.e. intravenous drug users), the association between genotype 1b and severe liver disease is still controversial.
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Monitoring of Human Cytomegalovirus Infections and Ganciclovir Treatment in Heart Transplant Recipients by Determination of Viremia, Antigenemia, and DNAemia
G. Gerna,Donato Zipeto,M. Parea,Maria Grazia Revello,Enrico Silini,Elena Percivalle,Maurizio Zavattoni,Paolo Grossi,Gabriele Milanesi +8 more
TL;DR: Follow-up of HCMV infections in heart transplant recipients showed that PCR can detect viral appearance in blood 7-10 days earlier than assays for antigenemia/viremia, and viral disappearance from blood, as assessed by PCR, occurred weeks or months later than revealed by other assays.
Journal ArticleDOI
Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities.
Enrico Silini,Fulvia Bono,A. Cividini,Antonella Cerino,S. Bruno,Sonia Rossi,Giovanni Belloni,Bruno Brugnetti,Emilio Civardi,Laura Salvaneschi,Mario U. Mondelli +10 more
TL;DR: Virological features of HCV infection might be associated with different clinical manifestations, suggesting a potential prognostic significance on disease outcome, and isolated genotype II was progressively more represented in advanced liver disease, such as cirrhosis and HCC.
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Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.
Fausto Baldanti,Mark R. Underwood,Sylvia C. Stanat,Karen K. Biron,Sunwen Chou,Antonella Sarasini,Enrico Silini,Giuseppe Gerna +7 more
TL;DR: It is demonstrated that the PFA resistance is associated with a slower replication of HCMV strains in cell cultures and may have some important implications for the successful isolation, propagation, and characterization of PFA-resistant strains from clinical samples containing mixed viral populations.