F
François Alhenc-Gelas
Researcher at French Institute of Health and Medical Research
Publications - 142
Citations - 6708
François Alhenc-Gelas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Angiotensin-converting enzyme & Renin–angiotensin system. The author has an hindex of 43, co-authored 141 publications receiving 6512 citations. Previous affiliations of François Alhenc-Gelas include University of Giessen & University of Texas System.
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Journal ArticleDOI
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
Florent Soubrier,François Alhenc-Gelas,Christine Hubert,Jacqueline Allegrini,Marie John,Geoffrey W. Tregear,Pierre Corvol +6 more
TL;DR: The sequence of ACE reveals a high degree of internal homology between two large domains, suggesting that the molecule resulted from a gene duplication, and is consistent with the presence of a single gene for ACE in the haploid human genome.
Journal ArticleDOI
Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications
Michel Marre,Pauline Bernadet,Yves Gallois,Frederique Savagner,Tham-Tam Guyene,M. Hallab,François Cambien,Phillippe Passa,François Alhenc-Gelas +8 more
TL;DR: Assessment of the relationship between the ACE gene polymorphism or plasma levels and microcirculatory disorders of IDDM and the II genotype of ACE gene is a marker for reduced risk for diabetic nephropathy reveals an imbalance of ACE genotype distribution.
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Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.
Michel Marre,Xavier Jeunemaitre,Yves Gallois,M. Rodier,Gilles Chatellier,C Sert,L Dusselier,Z Kahal,Lucy Chaillous,S Halimi,A Muller,H Sackmann,B. Bauduceau,F. Bled,Philippe Passa,François Alhenc-Gelas +15 more
TL;DR: Genetic determinants that affect renal angiotensin II and kinin productions are risk factors for the progression of glomerular disease in uncontrolled insulin-dependent diabetic patients.
Journal ArticleDOI
Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides.
TL;DR: The substrate specificity of the two active sites of ACE was compared using wild-type recombinant ACE and mutants, where one active site is suppressed by deletion or inactivated by mutations of 2 histidines coordinating an essential zinc atom, and suggests physiologically important differences between the subsites of theTwo active centers, and different substrate specificity, despite the high degree of sequence homology.
Journal Article
Distribution of plasma angiotensin I-converting enzyme levels in healthy men: relationship to environmental and hormonal parameters.
TL;DR: Plasma ACE levels have been determined by direct radioimmunoassay in a group of 434 healthy, middle-aged, Caucasian men and compared with several hemodynamic, environmental, and hormonal parameters.