G
Geoffrey W. Tregear
Researcher at University of Melbourne
Publications - 215
Citations - 9950
Geoffrey W. Tregear is an academic researcher from University of Melbourne. The author has contributed to research in topics: Relaxin & Relaxin receptor. The author has an hindex of 50, co-authored 215 publications receiving 9684 citations. Previous affiliations of Geoffrey W. Tregear include Prince Henry's Institute of Medical Research & Peking University.
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Journal ArticleDOI
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
Florent Soubrier,François Alhenc-Gelas,Christine Hubert,Jacqueline Allegrini,Marie John,Geoffrey W. Tregear,Pierre Corvol +6 more
TL;DR: The sequence of ACE reveals a high degree of internal homology between two large domains, suggesting that the molecule resulted from a gene duplication, and is consistent with the presence of a single gene for ACE in the haploid human genome.
Patent
Oligonucleotide-polyamide conjugates and methods of production and applications of the same
TL;DR: Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligon nucleotide Y, are also described in this article.
Journal ArticleDOI
Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family.
Ross A. D. Bathgate,Chrishan S. Samuel,Tanya C. D. Burazin,Sharon Layfield,Antonia A. Claasz,Irna Grace T. Reytomas,Nicola F. Dawson,Chongxin Zhao,Courtney Peta Bond,Roger J. Summers,Laura J. Parry,John D. Wade,Geoffrey W. Tregear +12 more
TL;DR: These data, together with the localization of transcripts in the pars ventromedialis of the dorsal tegmental nucleus of C57BLK6J mouse brain by in situhybridization histochemistry, suggest a new role for relaxin in neuropeptide signaling processes.
Journal ArticleDOI
Bovine Parathyroid Hormone: Minimum Chain Length of Synthetic Peptide Required for Biological Activity
Geoffrey W. Tregear,Jurphaas Van Rietschoten,Elizabeth Greene,Henry T. Keutmann,Hugh D. Niall,Barry Reit,J. A. Parsons,John T. Potts +7 more
TL;DR: It was found that deletion of the amino terminal residue (alanine) resulted in a marked decrease in activity and removal of the second residue (valine) at the amino terminus completely abolished activity in both assay systems.
Journal ArticleDOI
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
Chrishan S. Samuel,Elaine N. Unemori,Ishanee Mookerjee,Ross A. D. Bathgate,Sharon Layfield,John Mak,Geoffrey W. Tregear,Xiao-Jun Du +7 more
TL;DR: It is indicated that relaxin regulates fibroblast proliferation, differentiation, and collagen deposition and may have therapeutic potential in diseased states characterized by cardiac fibrosis.