Showing papers in "Journal of Laboratory and Clinical Medicine in 1991"

TL;DR: It is concluded that human serum globulins play a negligible role in acid-base equilibria, and that in normal human serum at pH 7.40 with [TP] = 7 and [Alb] = 4.3 gm/dl, the charges attributed to proteins are substantially less than the value given by many contemporary texts.

TL;DR: An important role for catalase in protection against H2O2-mediated damage at physiologic levels is suggested andcatalase is as at least as important as glutathione in cellular defense against H 2O2.

TL;DR: Plasma ACE levels have been determined by direct radioimmunoassay in a group of 434 healthy, middle-aged, Caucasian men and compared with several hemodynamic, environmental, and hormonal parameters.

TL;DR: It is concluded that plasma and ventricular fluid levels of IL-6 are elevated after head injury and that plasma IL-8 level is temporally related to acute phase reactants and clinical improvement and suggested that IL- 6 may play an etiologic role in many of the metabolic or nutritional sequelae of head injury.

TL;DR: Iron, by catalyzing the generation of the hydroxyl radical via the Haber-Weiss reaction, may participate in oxidant tissue injury, and whether iron might contribute to cigarette smoke-induced lung injury is estimated by measuring intracellular iron content of pulmonary macrophages and extracellularIron content of bronchoalveolar lavage fluid from cigarette smokers and nonsmokers.

TL;DR: The increased iron absorption in hereditary hemochromatosis is mediated primarily by an increase in the rate constant for transfer of mucosal iron to the plasma.

TL;DR: Using both modern serologic criteria complete with a history of asthma and radiologic findings, the diagnosis of allergic bronchopulmonary aspergillosis was made in 28 of 100 consecutive patients with asthma who had immediate cutaneous reactivity to Aspergillus fumigatus and who were seen in an outpatient setting.

TL;DR: Clinical investigations now have demonstrated the therapeutic efficacy of allopurinol in cutaneous leishmaniasis caused by Leishmania braziliensis and in chronic Chagas' Disease.

TL;DR: PDGF-BB appears to enhance the inflammatory phase of wound healing to indirectly trigger PC-I synthesis, whereas TGF-beta 1 quantitatively enhances PC- I synthesis directly, accounting for their differing duration of activities within healing wounds.

TL;DR: The favorable hemodynamic response to infusion of cross-linked hemoglobin solution after hemorrhage suggests that this material is comparable to autologous shed blood and superior to lactated Ringer's solution as a resuscitative fluid as assessed in this model.

TL;DR: The data suggest a protective role for serum amyloid A in thromboembolic disease by specific interaction with thrombin-induced platelet activation and homologous to the N-terminal portion of serum ameloid A, the observed activity probably resides in that part of the molecule.

TL;DR: The findings suggest that the presence of end-stage renal disease does not have a significant impact on the beta 2-microglobulin generation rate, and the degree of accumulation in patients undergoing hemodialysis seems to depend on the loss of renal excretory function.

TL;DR: Neutrophils from three siblings with cyclic neutropenia were studied to observe the effects of G-CSF treatment on neutrophil function in vivo, suggesting the involvement of guanine nucleotide-binding proteins (G-proteins).

TL;DR: Children and young adults with hyperuricemia had significantly higher plasma glucose and insulin levels, total cholesterol level, and serum triglyceride levels, and very-low-density lipoprotein cholesterol, low-density cholesterol, and total protein levels than subjects without hyperuricaemia; high-density lipid cholesterol level was significantly lower in subjects with hyperURicemia than in those without it.

TL;DR: It is concluded that the sensitivity for vasopressin secretion as well as the osmotic thresholds for thirst and vasoppressin demonstrate significant polygenetic variance among healthy adults.

TL;DR: System defibrinogenation with ancrod resulted in alteration of the character of abscess formation, as manifested by reduced abscess size and degree of purulence, and it is demonstrated that fibrin deposition contributes to the pathogenesis of purulentAbscess formation and that systemic depletion of fibrine may alter host susceptibility to the consequences of infection.

TL;DR: Staphylococci were found to have considerably greater osmoprotective activity, glycine betaine, and K+ than other organisms, even in the absence of external osmotic stress, may explain in part their remarkable salt tolerance and high turgor pressure.

TL;DR: It appears H2O2 can induce defects in signaling pathways with sequelae (decreased prostacyclin and platelet-activating factor) short of endothelial cell death.

TL;DR: Heparin, Usherdex 8, dextran sulfate 8000, and heparin demonstrate low, moderate, and high in vitro anticoagulant activity, respectively.

TL;DR: These studies demonstrate that orderly glycolysis in the erythrocyte is regulated by the NAD-to-NADH ratio and also provide a method that makes possible the in vitro study of ery Throatcyte glyCOlysis.

TL;DR: It is concluded that zinc therapy in Wilson's disease is not atherogenic, and the coronary heart disease risk factor remains below average in these patients after zinc therapy.

TL;DR: It is concluded that the medication history must be controlled in studies of cell function in asthma, and that albuterol may be preferable to isoproterenol as a premedication for bronchoscopy when superoxide production of airspace cells is studied.

TL;DR: The studies show that 5'NT activity may be a sensitive and useful indicator of mild deficiency of zinc in human subjects and that zinc levels in lymphocytes, granulocytes, and platelets decreased significantly only during the late zinc depletion phase.

TL;DR: These studies show genetic transmission of the isoleucine-122 transthyretin variant associated with this form of cardiac amyloidosis.

TL;DR: Rates of disappearance of TK mRNA and enzyme activity after peak levels were not significantly different by age and the incremental increase from baseline to peak was greater in the 1-year-old than in the 6-week-old rats.

TL;DR: A transient increase in GFR, ERPF, urine flow, and systemic blood pressure was seen after albumin administration, suggesting expansion of vascular volume as the initiating factor.

TL;DR: The 30,000 dalton native antigen of Mycobacterium tuberculosis is a major constituent of this organism and is secreted into culture medium and purified by ammonium sulfate precipitation, ion-exchange chromatography, and reverse-phase high-performance liquid chromatography to yield a single 29 to 30 kd component.

TL;DR: It is concluded that lead not only enhances LPS lethality but also TNF liver injury and increases LPS-stimulated serum TNF levels, suggesting that the lead-enhanced LPS model offers a system for studying TNF-induced liver injury.