F
François Jacob
Researcher at Pasteur Institute
Publications - 193
Citations - 27852
François Jacob is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Escherichia coli & Gene. The author has an hindex of 66, co-authored 192 publications receiving 26956 citations. Previous affiliations of François Jacob include Collège de France & University of California, Berkeley.
Papers
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Journal ArticleDOI
Genetic regulatory mechanisms in the synthesis of proteins.
François Jacob,Jacques Monod +1 more
TL;DR: The synthesis of enzymes in bacteria follows a double genetic control, which appears to operate directly at the level of the synthesis by the gene of a shortlived intermediate, or messenger, which becomes associated with the ribosomes where protein synthesis takes place.
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Allosteric Proteins and Cellular Control Systems
TL;DR: The biological activity of many proteins is controlled by specific metabolites which do not interact directly with the substrates or products of the reactions, and it is suggested that this mechanism plays an essential role in the regulation of metabolic activity.
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On the Regulation of DNA Replication in Bacteria
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The genetic control and cytoplasmic expression of “Inducibility” in the synthesis of β-galactosidase by E. coli
TL;DR: The study of galactosidase synthesis in heteromerozygotes of E. coli indicates that the z and i mutations belong to different cistrons, and the kinetics of expression of the i + (inducible) character suggest that the i gene controls the synthesis of a specific substance which represses the synthesis.