F
Francois Legay
Researcher at Novartis
Publications - 32
Citations - 1640
Francois Legay is an academic researcher from Novartis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 21 publications receiving 1544 citations.
Papers
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Journal ArticleDOI
Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury
Frank Dieterle,Elias Perentes,André Cordier,Daniel Robert Roth,P. F. Verdes,Olivier Grenet,Serafino Pantano,Pierre Moulin,Daniel Wahl,Andreas Mahl,Peter End,Frank Staedtler,Francois Legay,Kevin Carl,David Laurie,Salah-Dine Chibout,Jacky Vonderscher,Gerard Maurer +17 more
TL;DR: Gene and protein expression analysis, in-situ hybridization and immunohistochemistry provide mechanistic evidence to support the use of four previously described nephrotoxicity markers for detecting kidney injury to guide regulatory decision making in drug development.
Journal ArticleDOI
A randomized controlled trial with an anti-CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
Jasper J. Haringman,Danielle M. Gerlag,Tom J. M. Smeets,Dominique Baeten,Dominique Baeten,Filip Van den Bosch,Barry Bresnihan,Ferdinand C. Breedveld,Huib J. Dinant,Francois Legay,Hermann Gram,Pius Loetscher,Robert Schmouder,Thasia G. Woodworth,Paul P. Tak +14 more
TL;DR: In this article, the effects of human anti-CCL2/MCP-1 monoclonal antibody (ABN912) treatment in patients with rheumatoid arthritis (RA) were evaluated.
Journal ArticleDOI
A Panel of Urinary Biomarkers to Monitor Reversibility of Renal Injury and a Serum Marker With Improved Potential to Assess Renal Function
Josef S Ozer,Frank Dieterle,Sean P. Troth,Elias Perentes,André Cordier,P. F. Verdes,Frank Staedtler,Andreas Mahl,Olivier Grenet,Daniel Robert Roth,Daniel Wahl,Francois Legay,Daniel J. Holder,Zoltan Erdos,Katerina Vlasakova,Hong Jin,Yan Yu,Nagaraja Muniappa,Tom Forest,Holly K Clouse,Spencer Reynolds,Wendy J. Bailey,Douglas Thudium,Michael J Topper,Thomas R. Skopek,Joseph F. Sina,Warren E. Glaab,Jacky Vonderscher,Jacky Vonderscher,Gerard Maurer,Salah-Dine Chibout,Frank D. Sistare,David Gerhold +32 more
TL;DR: The authors' assay for serum cystatin C is more sensitive and specific than serum creatinine (SCr) or blood urea nitrogen (BUN) in monitoring generalized renal function after exposure of rats to eight nephrotoxicants and two hepatotoxicants.
Patent
Optical biosensor matrix
Veronique Briguet,Peter End,Francois Legay,Peter Marbach,Roland Pfefferkorn,Helmut Rudigier,Kurt Tiefenthaler,Alois Zetting +7 more
TL;DR: In this article, a detection cell is used as a component of an optical biosensor consisting of a transparent base plate (8) and a sample plate (4) on the base plate.
Journal ArticleDOI
Generation of Rabbit Monoclonal Antibody Fragments from a Combinatorial Phage Display Library and Their Production in the Yeast Pichia pastoris
TL;DR: The combinatorial immunoglobulin library and phage display technologies are applied to generate monoclonal rabbit single-chain Fv (scFv) antibody fragments specific for recombinant human leukemia inhibitory factor (rhLIF).