N
Nathalie Chaput
Researcher at Université Paris-Saclay
Publications - 39
Citations - 8857
Nathalie Chaput is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: T cell & Dendritic cell. The author has an hindex of 27, co-authored 39 publications receiving 7375 citations. Previous affiliations of Nathalie Chaput include French Institute of Health and Medical Research & Institut Gustave Roussy.
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Journal ArticleDOI
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vétizou,Marie Vétizou,Marie Vétizou,Jonathan M. Pitt,Jonathan M. Pitt,Jonathan M. Pitt,Romain Daillère,Romain Daillère,Romain Daillère,Patricia Lepage,Nadine Waldschmitt,Caroline Flament,Caroline Flament,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Bertrand Routy,Maria Paula Roberti,Maria Paula Roberti,Connie P.M. Duong,Connie P.M. Duong,Vichnou Poirier-Colame,Vichnou Poirier-Colame,Antoine Roux,Antoine Roux,Antoine Roux,Sonia Becharef,Sonia Becharef,Silvia C. Formenti,Encouse B. Golden,Sascha Cording,Gérard Eberl,Andreas Schlitzer,Florent Ginhoux,Sridhar Mani,Takahiro Yamazaki,Takahiro Yamazaki,Nicolas Jacquelot,Nicolas Jacquelot,Nicolas Jacquelot,David Enot,David Enot,Marion Bérard,Jérôme Nigou,Jérôme Nigou,Paule Opolon,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Paul Louis Woerther,Elisabeth Chachaty,Nathalie Chaput,Nathalie Chaput,Caroline Robert,Caroline Robert,Christina Mateus,Guido Kroemer,Didier Raoult,Ivo G. Boneca,Ivo G. Boneca,Franck Carbonnel,Mathias Chamaillard,Laurence Zitvogel +60 more
TL;DR: A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Journal ArticleDOI
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death.
Noelia Casares,Marie O. Pequignot,Antoine Tesniere,François Ghiringhelli,Stephan Roux,Nathalie Chaput,Elise Schmitt,Ahmed Hamaï,Sandra Hervas-Stubbs,Michel Obeid,Fréderic Philippe Coutant,Didier Métivier,Evelyne Pichard,Pierre Aucouturier,Gérard Pierron,Carmen Garrido,Laurence Zitvogel,Guido Kroemer +17 more
TL;DR: It is shown that even in the absence of any adjuvant, tumor cells dying in response to anthracyclins can elicit an effective antitumor immune response that suppresses the growth of inoculated tumors or leads to the regression of established neoplasia.
Journal ArticleDOI
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner
François Ghiringhelli,Cédric Ménard,Magali Terme,Caroline Flament,Julien Taieb,Nathalie Chaput,Pierre E. Puig,Sophie Novault,Bernard Escudier,Eric Vivier,A. Lecesne,Caroline Robert,Jean-Yves Blay,Jacky Bernard,Sophie Caillat-Zucman,Antônio C. Freitas,T. Tursz,Orianne Wagner-Ballon,Claude Capron,William Vainchencker,François Martin,Laurence Zitvogel +21 more
TL;DR: A role for T reg cells in blunting the NK cell arm of the innate immune system is supported in controlling innate antitumor immunity through inhibition of NK cell effector functions and down-regulated NKG2D receptors on theNK cell surface.
Journal ArticleDOI
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy.
Lionel Apetoh,François Ghiringhelli,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Carla Ortiz,Carla Ortiz,Carla Ortiz,Rosette Lidereau,Christophe Mariette,Nathalie Chaput,Nathalie Chaput,Jean-Paul Mira,Suzette Delaloge,Fabrice Andre,Thomas Tursz,Guido Kroemer,Guido Kroemer,Guido Kroemer,Laurence Zitvogel +22 more
TL;DR: It is shown that the release of the high mobility group box 1 protein by dying tumor cells is mandatory to license host dendritic cells (DCs) to process and present tumor antigens, and this knowledge may be clinically exploited to predict the immunogenicity and hence the efficacy of chemotherapeutic regimens.
Journal ArticleDOI
Exosomes: immune properties and potential clinical implementations
TL;DR: The conclusions of 20 years of studies on the immune properties of exosomes and the most recent advances on their roles and potential uses as markers or as therapeutic tools during pathologies, especially in cancer are described.