F
François Noël
Researcher at Federal University of Rio de Janeiro
Publications - 137
Citations - 2250
François Noël is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Na+/K+-ATPase & Ouabain. The author has an hindex of 24, co-authored 134 publications receiving 2092 citations. Previous affiliations of François Noël include Université catholique de Louvain.
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Journal ArticleDOI
Taurine prevents the neurotoxicity of β-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disorders
Paulo Roberto Louzada,Andréa C. Paula Lima,D. L. Mendonça-Silva,François Noël,Fernando G. de Mello,Sergio T. Ferreira +5 more
TL;DR: It is shown that tau¬rine, a β‐amino acid found at high concentrations in the brain, protects chick retinal neurons in culture against the neurotoxicity of Aβ and glutamate receptor ago¬nists and that pharmaco-logical manipulation of the excitatory and inhibitory neurotransmitter tonus may protect neurons against a variety of insults.
Journal ArticleDOI
Heterogeneity of ouabain specific binding sites and (Na+ + K+)-ATPase inhibition in microsomes from rat heart.
TL;DR: Cardiac glycoside binding to microsomes prepared from rat heart ventricles and enriched in (Na+ + K+)-ATPase was measured by a rapid filtration technique and it was observed that dihydroouabain, a ouabain derivative with a saturated lactone ring, competes with 3H-OUabain for the binding to the two classes of sites.
Journal ArticleDOI
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.
Neerja Kaushik-Basu,Alain Bopda-Waffo,Tanaji T. Talele,Amartya Basu,Paulo R. R. Costa,Alcides J. M. da Silva,Stefan G. Sarafianos,François Noël +7 more
TL;DR: Coumestans add to the diversifying pool of anti-NS5B agents and provide a novel scaffold for structural refinement and development of potent NS5B inhibitors.
Journal ArticleDOI
Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol.
Alcides J. M. da Silva,Camilla D. Buarque,Flávia V. Brito,Laure Aurelian,Luciana Macedo,Luciana Macedo,Linda H. Malkas,Robert J. Hickey,Robert J. Hickey,Daniele V.S. Lopes,François Noël,Yugo L. B. Murakami,Noelson M.V Silva,Paulo A. Melo,Rodrigo R.B. Caruso,Newton G. Castro,Paulo R. R. Costa +16 more
TL;DR: Seven new 1,4-naphthoquinones structurally related to lapachol were synthesized from lawsone and oxygenated arylmercurials, suggesting novel neuroactive structural motifs.
Journal ArticleDOI
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
Alcides J. M. da Silva,Paulo A. Melo,Noelson M.V Silva,Flávia V. Brito,Camilla D. Buarque,Daniele V de Souza,V.P. Rodrigues,Elisa Suzana Carneiro Pôças,François Noël,Edson X. Albuquerque,Edson X. Albuquerque,Paulo R. R. Costa +11 more
TL;DR: Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity.