S
Sergio T. Ferreira
Researcher at Federal University of Rio de Janeiro
Publications - 223
Citations - 14597
Sergio T. Ferreira is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Neuroprotection & Hydrostatic pressure. The author has an hindex of 61, co-authored 203 publications receiving 12213 citations. Previous affiliations of Sergio T. Ferreira include University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine
Fernanda G. De Felice,Fernanda G. De Felice,Pauline T. Velasco,Mary P. Lambert,Kirsten L. Viola,Sara J. Fernandez,Sergio T. Ferreira,William L. Klein +7 more
TL;DR: This response provides a pathologically specific mechanism for the therapeutic action of memantine, indicates a role for ROS dysregulation in ADDL-induced cognitive impairment, and supports the unifying hypothesis that ADDLs play a central role in AD pathogenesis.
Journal ArticleDOI
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim,Leticia Forny-Germano,Luciana B. Sathler,Jordano Brito-Moreira,Jean-Christophe Houzel,Helena Decker,Helena Decker,Michael A. Silverman,Hala Kazi,Helen M. Melo,Paula McClean,Christian Hölscher,Steven E. Arnold,Konrad Talbot,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +17 more
TL;DR: It is shown that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases, and establishes molecular links between the dysregulated insulin signaling in AD and diabetes.
Journal ArticleDOI
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
Fernanda G. De Felice,Marcelo N. N. Vieira,Theresa R. Bomfim,Helena Decker,Pauline T. Velasco,Mary P. Lambert,Kirsten L. Viola,Wei Qin Zhao,Sergio T. Ferreira,William L. Klein +9 more
TL;DR: The finding that synapse vulnerability to ADDLs can be mitigated by insulin suggests that bolstering brain insulin signaling, which can decline with aging and diabetes, could have significant potential to slow or deter AD pathogenesis.
Journal ArticleDOI
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease
TL;DR: Evidence indicating that inflammation, insulin resistance, and mitochondrial dysfunction are common features in AD and T2D are reviewed and the hypothesis that dementia and its underlying neuronal dysfunction are exacerbated or driven by peripheral inflammation is proposed.
Journal ArticleDOI
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Mychael V. Lourenco,Mychael V. Lourenco,Rudimar Luiz Frozza,Rudimar Luiz Frozza,Guilherme B. L. de Freitas,Guilherme B. L. de Freitas,Hong Zhang,Grasielle C. Kincheski,Felipe C. Ribeiro,Rafaella Araujo Gonçalves,Julia R. Clarke,Danielle Beckman,Agnieszka Staniszewski,Hanna Berman,Lorena A. Guerra,Leticia Forny-Germano,Shelby E. Meier,Donna M. Wilcock,Jorge Marcondes de Souza,Soniza Vieira Alves-Leon,Vania F. Prado,Marco A. M. Prado,Jose F. Abisambra,Fernanda Tovar-Moll,Paulo Mattos,Ottavio Arancio,Sergio T. Ferreira,Fernanda G. De Felice,Fernanda G. De Felice +28 more
TL;DR: FNDC5/irisin is placed as a novel agent capable of opposing synapse failure and memory impairment in AD, and restoration of its expression can ameliorate these phenotypes in rodent models.