F
Francois Stricher
Researcher at European Bioinformatics Institute
Publications - 36
Citations - 5818
Francois Stricher is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: FoldX & Meganuclease. The author has an hindex of 28, co-authored 36 publications receiving 5101 citations. Previous affiliations of Francois Stricher include Alternatives & Pompeu Fabra University.
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Journal ArticleDOI
The FoldX web server: an online force field
TL;DR: The core functionality of FoldX, namely the calculation of the free energy of a macromolecule based on its high-resolution 3D structure, is now publicly available through a web server at FoldX.
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How Protein Stability and New Functions Trade Off
TL;DR: The evolution of new enzymatic activities, both in nature and in the laboratory, is dependent on the compensatory, stabilizing effect of apparently “silent” mutations in regions of the protein that are irrelevant to its function.
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The stability effects of protein mutations appear to be universally distributed.
TL;DR: This bi-Gaussian model provides an analytical description of the predicted distributions of mutational stability effects and comprises a novel tool for analyzing proteins and protein models, for simulating the effect of mutations under evolutionary processes, and a quantitative description ofmutational robustness.
Journal ArticleDOI
Prediction of water and metal binding sites and their affinities by using the Fold-X force field
Joost Schymkowitz,Frederic Rousseau,Ivo C. Martins,Jesper Ferkinghoff-Borg,Francois Stricher,Luis Serrano +5 more
TL;DR: The accuracy of the energy prediction presented here is sufficient to efficiently discriminate between Mg2+, Ca2+, and Zn2+ binding, allowing one to discriminate between high- and low-affinity binding sites.
Journal ArticleDOI
Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets.
Sylvain Arnould,Patrick Chames,Christophe Perez,Emmanuel Lacroix,Aymeric Duclert,Jean-Charles Epinat,Francois Stricher,Anne-Sophie Petit,Amélie Patin,Sophie Guillier,Sandra Rolland,Jesús Prieto,Francisco J. Blanco,Jerónimo Bravo,Guillermo Montoya,Luis Serrano,Philippe Duchateau,Frédéric Pâques +17 more
TL;DR: It is shown that a semi-rational approach can be used to derive hundreds of novel proteins from I-CreI, a homing endonuclease from the LAGLIDADG family, and rules for protein/DNA interaction can be inferred from statistical analysis.