F
Francois-Xavier Mahon
Researcher at University of Bordeaux
Publications - 293
Citations - 12100
Francois-Xavier Mahon is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Imatinib mesylate & Myeloid leukemia. The author has an hindex of 44, co-authored 282 publications receiving 10491 citations. Previous affiliations of Francois-Xavier Mahon include University of Thessaly & Imperial College Healthcare.
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Journal ArticleDOI
Predicting complete cytogenetic response in chronic myelogenous leukemia patients treated with recombinant interferon alpha [letter; comment]
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Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.
Arnaud Pigneux,Francois-Xavier Mahon,Maialene Uhalde,Marie Jeanneteau,Francis Lacombe,Noel Milpied,Josy Reiffers,Francis Belloc +7 more
TL;DR: The results suggest that, by modifying the cell cycle kinetics, AraC sensitizes AML cells to apoptosis induced by low concentration triptolide, which warrants further clinical investigation for treatment of AML patients, especially elderly patients for whom low-dose AraC treatment could be improved by the addition of triPTolide.
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ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+) CD38(-) population to imatinib.
Kelly Airiau,Francois-Xavier Mahon,Marina Josselin,Marie Jeanneteau,Beatrice Turcq,Francis Belloc +5 more
TL;DR: ABT-737 and TKI cooperate at several levels to induce apoptosis of CML cells lines, and the benefit of this association was also observed in CML hematopoietic progenitors, and a lethal effect wasAlso observed in the more immature CD34(+)CD38(-) TKI-insensitive population.
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Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.
Peter Valent,Karl Sotlar,Katharina Blatt,Karin Hartmann,Andreas Reiter,Irina Sadovnik,Wolfgang R. Sperr,Peter Bettelheim,Cem Akin,Karin Bauer,Tracy I. George,Emir Hadzijusufovic,D. Wolf,Jason Gotlib,Francois-Xavier Mahon,Dean D. Metcalfe,H.-P. Horny,Michel Arock +17 more
TL;DR: Criteria and classification proposed in this article should facilitate the diagnosis and management of patients with unexplained basophilia and basophil neoplasms in routine practice, and in clinical studies.
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Quantification of the Mutant CALR Allelic Burden by Digital PCR: Application to Minimal Residual Disease Evaluation after Bone Marrow Transplantation
Olivier Mansier,Marina Migeon,Arnaud Saint-Lézer,Chloé James,Emmanuelle Verger,Marie Robin,Gérard Socié,Audrey Bidet,Francois-Xavier Mahon,Bruno Cassinat,Eric Lippert +10 more
TL;DR: Digital PCR adapted to type 1 and 2 CALR mutations is an inexpensive, highly precise, and sensitive technique suitable for evaluation of myeloproliferative neoplasm patients during follow-up.