C
Cem Akin
Researcher at University of Michigan
Publications - 248
Citations - 14376
Cem Akin is an academic researcher from University of Michigan. The author has contributed to research in topics: Systemic mastocytosis & Mast cell. The author has an hindex of 54, co-authored 208 publications receiving 12065 citations. Previous affiliations of Cem Akin include National Institutes of Health & Nichirei Corporation.
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Journal ArticleDOI
Diagnostic criteria and classification of mastocytosis: a consensus proposal
Peter Valent,Hans P. Horny,Luis Escribano,B. Jack Longley,Chin Y. Li,Lawrence B. Schwartz,Gianni Marone,Rosa Núñez,Cem Akin,Karl Sotlar,Wolfgang R. Sperr,Klaus Wolff,Richard D. Brunning,Reza Parwaresch,K. Frank Austen,Karl Lennert,Dean D. Metcalfe,James W. Vardiman,John M. Bennett +18 more
TL;DR: Criteria to delineate categories of mastocytosis together with an updated consensus classification system are proposed and proposed, based on typical clinical and histological skin lesions and absence of definitive signs (criteria) of systemic involvement.
Journal ArticleDOI
Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria.
Peter Valent,Cem Akin,Luis Escribano,Manuela Födinger,Karin Hartmann,Knut Brockow,Mariana Castells,Wolfgang R. Sperr,Hanneke C. Kluin-Nelemans,N. A. T. Hamdy,Olivier Lortholary,Jamie Robyn,J. J. Van Doormaal,Karl Sotlar,Alexander W. Hauswirth,Michel Arock,Olivier Hermine,Andrzej Hellmann,Massimo Triggiani,Marek Niedoszytko,Lawrence B. Schwartz,A. Orfao,Hans-Peter Horny,Dean D. Metcalfe +23 more
TL;DR: Recommendations and algorithms should greatly facilitate the management of patients with mastocytosis in clinical practice, selection of patients for therapies, and the conduct of clinical trials.
Journal ArticleDOI
Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal
Peter Valent,Cem Akin,Michel Arock,Knut Brockow,Joseph H. Butterfield,Melody C. Carter,Mariana Castells,Luis Escribano,Karin Hartmann,Philip Lieberman,Bogusław Nedoszytko,Alberto Orfao,Lawrence B. Schwartz,Karl Sotlar,Wolfgang R. Sperr,Massimo Triggiani,Rudolf Valenta,Hans-Peter Horny,Dean D. Metcalfe +18 more
TL;DR: Criteria for diagnosing MCA and related disorders are defined by robust and generally applicable criteria and should assist in the identification and diagnosis of patients with MCAS, and in avoiding misdiagnoses or overinterpretation of clinical symptoms in daily practice.
Journal ArticleDOI
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI
Arnold S. Kirshenbaum,Cem Akin,Yalin Wu,Menachem Rottem,Julie P. Goff,Michael A. Beaven,V.Koneti Rao,Dean D. Metcalfe +7 more
TL;DR: Two novel stem cell factor (SCF) dependent human mast cell lines were established from bone marrow aspirates from a patient with mast cell sarcoma/leukemia, offering an unparalleled circumstance to examine the biology of human mast cells.
Journal ArticleDOI
Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
TL;DR: An overview of recent developments in the field of mastocytosis is provided, with emphasis on the updated WHO classification, refined criteria, additional prognostic parameters, and novel therapeutic approaches.