F
Frank Grosse
Researcher at Institute of Molecular Biotechnology
Publications - 21
Citations - 1675
Frank Grosse is an academic researcher from Institute of Molecular Biotechnology. The author has contributed to research in topics: DNA & Primase. The author has an hindex of 18, co-authored 21 publications receiving 1619 citations.
Papers
More filters
Journal ArticleDOI
Production of spider silk proteins in tobacco and potato
TL;DR: The accumulation of recombinant silk proteins, which are encoded by synthetic genes of 420–3,600 base pairs, up to a level of at least 2% of total soluble protein in the endoplasmic reticulum of tobacco and potato leaves and potato tubers, respectively are demonstrated.
Journal ArticleDOI
p53 Protein Exhibits 3′-to-5′ Exonuclease Activity
Torsten Mummenbrauer,Friedemann Janus,Beate Müller,Lisa Wiesmüller,Wolfgang Deppert,Frank Grosse +5 more
TL;DR: A p53-intrinsic exonuclease activity is intrinsic to the wild-type p53 protein and should substantially extend the view on the role of p53 as a "guardian of the genome".
Journal ArticleDOI
Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.
TL;DR: The dual role model for p53 in maintaining genomic integrity significantly enhances p53's possibilities as a guardian of the genome.
Journal ArticleDOI
The dual role model for p53 in maintaining genomic integrity.
Friedemann Janus,Nils Albrechtsen,Irene Dornreiter,Lisa Wiesmüller,Frank Grosse,Wolfgang Deppert +5 more
TL;DR: It is proposed that p53 exerts its functions as a ‘guardian of the genome’ at various levels in its noninduced state, and may be actively involved in prevention and repair of endogenous DNA damage.
Journal ArticleDOI
Domain structure of human nuclear DNA helicase II (RNA helicase A).
Suisheng Zhang,Frank Grosse +1 more
TL;DR: A model is suggested in which the flanking domains influence and regulate the unwinding properties of NDH II, a full-length human nuclear DNA helicase II was cloned and overexpressed in a baculovirus-derived expression system.