Showing papers by "Franz Oesch published in 1972"
TL;DR: Evidence suggests that a coupled monooxygenase-hydrase system, inducible by 3-methylcholanthrene, is present in liver microsomes and may convert aromatic compounds rapidly to dihydrodiols, thereby circumventing toxic effects of intermediate arene oxides.
153 citations
Journal Article•
TL;DR: Mouse skin tumorigenesis initiated by 7,12-dimethylbenz[ a ]anthracene and promoted by repeated applications of phorbol ester is unrelated to genetic diffrences in the extent of aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons in inbred or hybrid C57BL/6N and DBA/2N mice.
Abstract: Mouse skin tumorigenesis initiated by 7,12-dimethylbenz[ a ]anthracene and promoted by repeated applications of phorbol ester is unrelated to genetic diffrences in the extent of aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons in inbred or hybrid C57BL/6N and DBA/2N mice. Thus, if aryl metabolism of 7,12-dimethylbenz[ a ] anthracene is a necessary step in the initiation of chemical carcinogenesis, the constitutive level of the hydroxylase activity in the skin of these mice is sufficient, Levels of hepatic epoxide hydrase activity are the same among inbred and hybrid C57BL/6N and DBA/2N mice and, in contrast to the hydroxylase, are not inducible by 3-methylcholanthrene. Epoxide hydrase activity could not be detected in the skin of these mice.
ACKNOWLEDGMENT We thank Francine Goujon and Noreen Morris for valuable technical assistance.
63 citations
TL;DR: Cytochrome P -450 and P -448 fractions isolated from rat liver microsomes contain high levels of epoxide hydrase activity with styrene oxide or naphthalene-1,2-oxide as substrate, and its conversion to dihydrodiol can be blocked by the epoxidehydrase inhibitor, 3,3,3-trichloropropene oxide.
63 citations
4 citations