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Anthony Y. H. Lu
Researcher at Hoffmann-La Roche
Publications - 83
Citations - 6483
Anthony Y. H. Lu is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cytochrome & Microsome. The author has an hindex of 45, co-authored 83 publications receiving 6436 citations.
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Journal ArticleDOI
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
TL;DR: The results indicate that the cytochrome P-450 and P-448 fractions have different substrate specificities and are consistent with the view that cytochromes P- 450 andP-448 are different hemoproteins.
Journal ArticleDOI
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Anthony Y. H. Lu,Wayne Levin +1 more
TL;DR: Cytochromes P-450 and P-448 were solubilized and partially purified from rat liver microsomes and exhibited different substrate specificities for benzphetamine and 3,4-benzpyrene.
Journal ArticleDOI
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
Jiunn H. Lin,Anthony Y. H. Lu +1 more
TL;DR: A review examines the sources that are responsible for the large interindividual variability in response to enzyme inhibition and induction of cytochrome P450 enzymes.
Journal ArticleDOI
Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.
Dhiren R. Thakker,Haruhiko Yagi,H. Akagi,Masato Koreeda,Anthony Y. H. Lu,Wayne Levin,Alexander W. Wood,Allan H. Conney,Donald M. Jerina +8 more
TL;DR: The stereospecificity of both the monoxygenase system and, to a lesser extent, epoxide hydrase plays important roles in the metabolic activation of benzo[a]pyrene to carcinogens and mutagens.
Journal ArticleDOI
CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies
Qiang Ma,Anthony Y. H. Lu +1 more
TL;DR: The understanding of the interrelation between CYP1A induction and chemical safety has followed a full circle and underscores the importance of whole animal and human studies in chemical safety evaluation.