F
Fred H. Menko
Researcher at Netherlands Cancer Institute
Publications - 167
Citations - 15540
Fred H. Menko is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 57, co-authored 163 publications receiving 14553 citations. Previous affiliations of Fred H. Menko include VU University Medical Center & VU University Amsterdam.
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Journal ArticleDOI
Experience of discharge from colonoscopy of mutation negative HNPCC family members
E. M. A. Bleiker,Fred H. Menko,B. G. Taal,Irma Kluijt,L.D.V. Wever,Miranda A. Gerritsma,Hans F. A. Vasen,Neil K. Aaronson +7 more
TL;DR: In HNPCC, two important goals of genetic testing are to identify those with a high risk of developing colorectal cancer to promote preventive strategies and reduce morbidity and mortality; and to reduce unnecessary worry amongThose with a low risk of cancer (mutation negative).
Journal ArticleDOI
The uptake of predictive DNA testing in 40 families with a pathogenic BRCA1/BRCA2 variant. An evaluation of the proband-mediated procedure.
Fred H. Menko,Kiki N Jeanson,Eveline M. A. Bleiker,Carla W M van Tiggelen,Frans B. L. Hogervorst,Jacqueline A Ter Stege,Daoud Ait Moha,Lizet E. van der Kolk +7 more
TL;DR: The standard proband-mediated procedure of informing relatives seems to be far from optimal, and a tailored approach is suggested for each family, including the option of a direct approach to at-risk family members by the geneticist.
Journal ArticleDOI
Late-onset common cancers in a kindred with an Arg213Gln TP53 germline mutation.
Marielle W. G. Ruijs,Senno Verhoef,G. Wigbout,Roelof Pruntel,Arno Floore,Daphne de Jong,Laura van 't Veer,Fred H. Menko +7 more
TL;DR: The findings suggest that this TP53 germline mutation is a causative factor in this family and that specific TP 53 germline mutations can be associated with relatively late-onset common cancers.
Journal ArticleDOI
The effectiveness of a graphical presentation in addition to a frequency format in the context of familial breast cancer risk communication: a multicenter controlled trial
Lidewij Henneman,Jan C. Oosterwijk,Christi J. van Asperen,Fred H. Menko,Caroline F. Ockhuysen-Vermey,Piet J. Kostense,Liesbeth Claassen,Danielle R.M. Timmermans +7 more
TL;DR: Women’s personal risk estimation accuracy was generally high at baseline and the results suggest that an additional graphical display does not lead to a significant benefit in terms of increasing understanding of risk, psychological well-being and preventive intentions.
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Spontaneous pneumothorax as indicator for Birt-Hogg-Dubé syndrome in paediatric patients
Paul C Johannesma,Ben E. E. M. van den Borne,Johannes J P Gille,Ad F. Nagelkerke,Jan-Hein T M van Waesberghe,Marinus A. Paul,R. Jeroen A. van Moorselaar,Fred H. Menko,Pieter E. Postmus +8 more
TL;DR: Two patients with (recurrent) pneumothorax starting at age 14 accompanied by multiple basal lung cysts on thoracic CT underwent FLCN germline mutation analysis, confirming suspected BHD and illustrating that BHD should be considered as cause of SP in children.