F
Fred H. Menko
Researcher at Netherlands Cancer Institute
Publications - 167
Citations - 15540
Fred H. Menko is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 57, co-authored 163 publications receiving 14553 citations. Previous affiliations of Fred H. Menko include VU University Medical Center & VU University Amsterdam.
Papers
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Journal ArticleDOI
Informing family members of individuals with Lynch syndrome: a guideline for clinical geneticists
Fred H. Menko,Cora M. Aalfs,Lidewij Henneman,Yrrah Stol,Miranda Wijdenes,Ellen Otten,Marleen M. J. Ploegmakers,Johan Legemaate,Ellen M. A. Smets,Guido de Wert,Aad Tibben,Aad Tibben +11 more
TL;DR: Development of a revised guideline for clinical geneticists that allows a more active role of the geneticist, aimed at improving procedures to inform family members in Lynch syndrome and other hereditary and familial cancer syndromes is summarized.
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Comparative genomic hybridization of microdissected familial ovarian carcinoma: two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma.
Ronald P. Zweemer,Andy Ryan,Antoine M. Snijders,Mario A. J. A. Hermsen,Gerrit A. Meijer,Uziel Beller,Fred H. Menko,Ian Jacobs,Jan P. A. Baak,René H.M. Verheijen,Peter Kenemans,Paul J. van Diest +11 more
TL;DR: To characterize further differences between hereditary and sporadic cancers, the comparative genomic hybridization technique was employed to analyze changes in copy number of genetic material in a panel of 36 microdissected hereditary ovarian cancers and revealed that the majority of genetic alterations are also common in sporadic ovarian cancer.
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The contribution of CHEK2 to the TP53 -negative Li-Fraumeni phenotype
Marielle W. G. Ruijs,Marielle W. G. Ruijs,Annegien Broeks,Fred H. Menko,Margreet G. E. M. Ausems,Anja Wagner,Rogier A. Oldenburg,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Laura J. van't Veer,Senno Verhoef +10 more
TL;DR: The data show that CHEK2 is not a major LFS susceptibility gene in the Dutch population, however, it might be a factor contributing to individual tumour development in TP53-negative cancer-prone families.
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Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and fallopian tube in women at hereditary high risk of breast and ovarian cancer
Brenda B.J. Hermsen,Paul J. van Diest,Johannes Berkhof,Fred H. Menko,Johan J.P. Gille,Jurgen M.J. Piek,Sybren L. Meijer,Henri A. H. Winters,Peter Kenemans,Silvia von Mensdorff-Pouilly,René H.M. Verheijen +10 more
TL;DR: The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk of breast and/or ovarian cancers.
Journal ArticleDOI
Risk of spontaneous pneumothorax due to air travel and diving in patients with Birt-Hogg-Dubé syndrome.
Paul C Johannesma,I. van de Beek,J. W. T. van der Wel,Marinus A. Paul,Arjan C. Houweling,Marianne A. Jonker,J.H.T.M. van Waesberghe,Rinze Reinhard,Th. M. Starink,R.J.A. Van Moorselaar,Fred H. Menko,Pieter E. Postmus,Pieter E. Postmus +12 more
TL;DR: Exposure of BHD patients to considerable changes in atmospheric pressure associated with flying and diving may be related to an increased risk for developing a symptomatic pneumothorax.