F
Fred H. Menko
Researcher at Netherlands Cancer Institute
Publications - 167
Citations - 15540
Fred H. Menko is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 57, co-authored 163 publications receiving 14553 citations. Previous affiliations of Fred H. Menko include VU University Medical Center & VU University Amsterdam.
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Journal ArticleDOI
Humoral immune responses to MUC1 in women with a BRCA1 or BRCA2 mutation
Brenda B.J. Hermsen,R.H.M. Verheijen,Fred H. Menko,Johan J.P. Gille,K. van Uffelen,Marinus A. Blankenstein,Sybren L. Meijer,P. J. Van Diest,Peter Kenemans,S. von Mensdorff-Pouilly +9 more
TL;DR: Serum levels of natural IgG ab to MUC1 are lower in BRCA1/2 mutation carriers than in healthy controls, strengthening tumour immune surveillance, and in contrast to previous results in women with sporadic breast cancer, no elevated M UC1 IgGAb ab were seen in women at hereditary high risk of breast cancer.
Journal ArticleDOI
Design of the BRISC study: a multicentre controlled clinical trial to optimize the communication of breast cancer risks in genetic counselling
Caroline F. Ockhuysen-Vermey,Lidewij Henneman,Christi J. van Asperen,Jan C. Oosterwijk,Fred H. Menko,Danielle R.M. Timmermans +5 more
TL;DR: The BRISC study allows for an evaluation of the effects of different formats of communicating breast cancer risks to counsellees and can be used to optimize risk communication in order to improve informed decision-making among women with a family history of breast cancer.
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Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry
Hans F. A. Vasen,Mary E. Velthuizen,Jan H. Kleibeuker,Fred H. Menko,Fokke M Nagengast,Annemieke Cats,Andrea E. van der Meulen-de Jong,Martijn H. Breuning,Anne J. Roukema,Inge van Leeuwen-Cornelisse,Wouter H. de Vos tot Nederveen Cappel,Juul T. Wijnen +11 more
TL;DR: The Dutch Hereditary Cancer Registry was established in 1985 and evaluation of the effect of registration and colonoscopic surveillance on the mortality rate associated with colorectal cancer (CRC) showed that the policy led to a substantial decrease in the deaths associated with CRC.
Journal Article
C, p.Asn38His, in six families with Lynch syndrome
E. van Riel,M.G.E.M. Ausems,Frans B. L. Hogervorst,Irma Kluijt,M.E. van Gijn,J van Echtelt,K. Scheidel-Jacobse,Eric A. M. Hennekam,Rein P. Stulp,Yvonne J. Vos,G. J. A. Offerhaus,Fred H. Menko,Johan J.P. Gille,Vu,VU medisch centrum +14 more
TL;DR: The UV in exon 1 of the MLH1 gene is a pathogenic mutation and genealogy and haplotype analysis results strongly suggest that it is a Dutch founder mutation, implying that predictive testing can be offered to healthy family members.
Journal ArticleDOI
Genetic counseling does not fulfill the counselees' need for certainty in hereditary breast/ovarian cancer families: an explorative assessment
Joel Vos,Fred H. Menko,Jan C. Oosterwijk,Christi J. van Asperen,Anne M. Stiggelbout,Aad Tibben,Aad Tibben +6 more
TL;DR: In this article, the authors explored the balance between the counselees' need for certainty and perceived certainty (NfC-PC) regarding the specific domains of DNA test result, heredity and cancer.