Frederico Aires-da-Silva

TL;DR: Advances in the development and engineering of therapeutic BBB-crossing antibodies and their high potential for treatment of CNS disorders are reviewed.

TL;DR: A panel of heme‐specific single domain antibodies (sdAbs) that neutralize the pro‐oxidant activity of soluble heme in vitro are developed and characterized, suggesting that these maybe used to counter the pathologic effects of labile heme during hemolytic conditions.

TL;DR: In this paper, the applicability of antibiotic encapsulated liposomes as an effective therapeutic strategy for bacterial infections is discussed, which holds the potential to overcome antimicrobial resistance and biofilm formation and constituting a promising solution for the treatment of potential fatal multidrug resistant bacterial infections, such as methicillin resistant Staphylococcus aureus.

TL;DR: In this article, the authors provide a general overview of chemokine effects on several tumoral processes, as well as a description of the currently available chemokin-directed therapies, highlighting their potential both as monotherapy or in combination with standard chemotherapy or other immunotherapies.

TL;DR: It is shown that specific domains of Dengue virus type 2 capsid protein (DEN2C) can be used as trans-BBB peptide vectors and their mechanism of translocation is receptor-independent and consistent with adsorptive-mediated transport (AMT).