Fredrik Karlsson

TL;DR: This work uses shotgun sequencing to characterize the faecal metagenome of 145 European women with normal, impaired or diabetic glucose control, and develops a mathematical model based on metagenomic profiles that identified T2D with high accuracy.

TL;DR: It is demonstrated that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls.

TL;DR: It is suggested that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.

TL;DR: The use of genetically engineered gnotobiotic mouse models may increase the understanding of mechanisms by which the gut microbiome modulates host metabolism and physiology, and a combination of classical microbiology, sequencing, and animal experiments may provide further insights.

TL;DR: This work reconstructed GEMs for three key species, (Bacteroides thetaiotamicron, Eubacterium rectale and Methanobrevibacter smithii) as relevant representatives of three main phyla in the human gut and demonstrated that these models can be used as a scaffold for understanding bacterial interactions in the gut.