F
Friedrich Grimminger
Researcher at University of Giessen
Publications - 431
Citations - 33019
Friedrich Grimminger is an academic researcher from University of Giessen. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 83, co-authored 402 publications receiving 30002 citations. Previous affiliations of Friedrich Grimminger include Goethe University Frankfurt.
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Journal ArticleDOI
Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.
Markus Roth,Markus Rupp,Simone Hofmann,Manish Mittal,Beate Fuchs,Natascha Sommer,Nirmal Parajuli,Karin Quanz,Dominic Schubert,Eva Dony,Ralph T. Schermuly,Hossein Ardeschir Ghofrani,Ulrike Sausbier,Katrin Rutschmann,Sarah Wilhelm,Werner Seeger,Peter Ruth,Friedrich Grimminger,Matthias Sausbier,Norbert Weissmann +19 more
TL;DR: It is demonstrated that neither deletion of HO-2 nor BK channels affect acute, sustained, and chronic vascular responses to alveolar hypoxia in the lung.
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Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle
Himal Luitel,Akylbek Sydykov,Yves Schymura,Argen Mamazhakypov,Wiebke Janssen,Wiebke Janssen,Kabita Pradhan,Astrid Wietelmann,Djuro Kosanovic,Bhola K. Dahal,Norbert Weissmann,Werner Seeger,Werner Seeger,Friedrich Grimminger,Hossein Ardeschir Ghofrani,Ralph T. Schermuly +15 more
TL;DR: The time course of structural and functional changes in the RV in the murine model of pressure overload‐induced RV hypertrophy in C57Bl/6J mice is investigated to suggest possible involvement of mast cells inThe RV remodeling process in response to pressure overload.
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Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography.
Rajkumar Savai,Joachim Claudius Wolf,Susanne Greschus,B. Eul,Ralph T. Schermuly,Jörg Hänze,Robert Voswinckel,Alexander C. Langheinrich,Friedrich Grimminger,Horst Traupe,Werner Seeger,Frank Rose +11 more
TL;DR: In this model of peripheral parenchymal malignancy, new imaging techniques allowed effective visualization of lung tumor growth and vascularization in living mice, demonstrating a pulmonary blood supply for lung tumors.
Journal ArticleDOI
Inhaled Tolafentrine Reverses Pulmonary Vascular Remodeling via Inhibition of Smooth Muscle Cell Migration
Soni Savai Pullamsetti,Stefanie Krick,Hüseyin Yilmaz,Hossein Ardeschir Ghofrani,Christian Schudt,Norbert Weissmann,Beate Fuchs,Werner Seeger,Friedrich Grimminger,Ralph T. Schermuly +9 more
TL;DR: It is demonstrated for the first time that inhalation of combined PDE3/4 inhibitor reverses pulmonary hypertension fully developed in response to monocrotaline in rats.
Journal ArticleDOI
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
Ralph T. Schermuly,Christiane Inholte,Hossein Ardeschir Ghofrani,Henning Gall,Norbert Weissmann,Andreas Weidenbach,Werner Seeger,Friedrich Grimminger +7 more
TL;DR: It is concluded that co-administration of minute systemic doses of selective PDE inhibitors with inhaled iloprost markedly enhances and prolongs the pulmonary vasodilatory response to inhaled Iloprost, with maintenance of pulmonary selectivity and ventilation perfusion matching.