Friedrich Grimminger

TL;DR: Findings substantiate the major role of PDGFR activation in pulmonary vascular remodeling by a genetic approach and suggest a role for SDF-1α/CXCR4 axis in pulmonaryascular remodeling and point to a potential interaction between the chemokine SDF -1 and the growth factor PDGF signaling.

TL;DR: Data suggest that the state of actin polymerization is intimately linked to the exocytosis process underlying surfactant secretion in AET2, and microfilament system-related compartmentalization effects and/or or the impact of the stateof actin assembly on signaling events may be considered as underlying events.

TL;DR: Azaindole-1 provided therapeutic benefit in experimental PH, and this may be attributable to its potent vasorelaxant and antiproliferative effects and may offer a useful approach for treatment of PH.

TL;DR: The application of inhaled treprostinil with a metered dose inhaler is feasible and well tolerated and induced a sustained pulmonary selective vasodilatation.

TL;DR: Investigation of the effect of bacterial lipopolysaccharides on tumor proliferation in vitro in the non-small cell lung cancer cell line A549 revealed that the proliferative effect of LPS was dependent on CD14 and Toll-like receptor (TLR)4 and blocking of the epidermal growth factor receptor (EGFR) also decreased LPS-induced proliferation of A549 cells.