R
Rajkumar Savai
Researcher at Max Planck Society
Publications - 147
Citations - 6469
Rajkumar Savai is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 40, co-authored 109 publications receiving 4996 citations. Previous affiliations of Rajkumar Savai include University of Giessen & Goethe University Frankfurt.
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Journal ArticleDOI
Reversal of experimental pulmonary hypertension by PDGF inhibition.
Ralph T. Schermuly,Eva Dony,Hossein Ardeschir Ghofrani,Soni Savai Pullamsetti,Rajkumar Savai,Markus Roth,Akylbek Sydykov,Ying Ju Lai,Norbert Weissmann,Werner Seeger,Friedrich Grimminger +10 more
TL;DR: STI571 reverses vascular remodeling and cor pulmonale in severe experimental pulmonary hypertension regardless of the initiating stimulus, and offers a unique novel approach for antire-modeling therapy in progressed pulmonary hypertension.
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Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.
Rajkumar Savai,Soni Savai Pullamsetti,Julia Kolbe,Ewa Bieniek,Robert Voswinckel,Ludger Fink,A. Scheed,Christin Ritter,Bhola K. Dahal,Axel Vater,Sven Klussmann,Hossein Ardeschir Ghofrani,Norbert Weissmann,Walter Klepetko,Gamal Andre Banat,Werner Seeger,Friedrich Grimminger,Ralph T. Schermuly +17 more
TL;DR: In this article, the number and cross-sectional distribution of inflammatory cells in different sizes of pulmonary arteries from explanted lungs of patients with idiopathic pulmonary arterial hypertension versus healthy donor lungs were evaluated.
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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
Rajkumar Savai,Hamza M. Al-Tamari,Daniel Sedding,Baktybek Kojonazarov,Christian Muecke,Rebecca Teske,Mario R. Capecchi,Norbert Weissmann,Friedrich Grimminger,Werner Seeger,Ralph T. Schermuly,Soni Savai Pullamsetti +11 more
TL;DR: It is shown that in pulmonary vessels and PASMCs of human and experimental PH lungs, FoxO1 expression is downregulated and FoxO 1 is inactivated via phosphorylation and nuclear exclusion.
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Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy
Xiang Zheng,Kati Turkowski,Javier Mora,Bernhard Brüne,Werner Seeger,Andreas Weigert,Rajkumar Savai +6 more
TL;DR: This review summarizes current strategies for cancer intervention via manipulation of macrophage polarization, with particular focus on composition of the tumor microenvironment and its influence on cancer progression and metastasis.
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Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension
Soni Savai Pullamsetti,Carmen Doebele,Ariane Fischer,Rajkumar Savai,Baktybek Kojonazarov,Bhola K. Dahal,Hossein Ardeschir Ghofrani,Norbert Weissmann,Friedrich Grimminger,Angelika Bonauer,Werner Seeger,Andreas M. Zeiher,Stefanie Dimmeler,Ralph T. Schermuly +13 more
TL;DR: It is demonstrated that A-17 improves heart and lung function in experimental PH by interfering with lung vascular and right ventricular remodeling and may represent a novel therapeutic concept to ameliorate disease state in PH.