F
Friedrich Grimminger
Researcher at University of Giessen
Publications - 431
Citations - 33019
Friedrich Grimminger is an academic researcher from University of Giessen. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 83, co-authored 402 publications receiving 30002 citations. Previous affiliations of Friedrich Grimminger include Goethe University Frankfurt.
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Journal ArticleDOI
Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function
Frank Reichenberger,Markus G. Kohstall,Timon Seeger,Horst Olschewski,Friedrich Grimminger,Werner Seeger,Hossein Ardeschir Ghofrani +6 more
TL;DR: It is concluded that in healthy individuals, exposure to acute hypoxia and sojourns at high altitude result in a small but significant increase in sPAP accompanied by an impairment of right ventricular function.
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Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice.
Kabita Pradhan,Akylbek Sydykov,Xia Tian,Argen Mamazhakypov,Balram Neupane,Himal Luitel,Norbert Weissmann,Werner Seeger,Friedrich Grimminger,Axel Kretschmer,Johannes-Peter Stasch,Hossein Ardeschir Ghofrani,Ralph T. Schermuly +12 more
TL;DR: Modulation of the NO-sGC-cGMP pathway by the PDE5 inhibitor sildenafil or sGC stimulator riociguat exerts direct beneficial effects on pulmonary hemodynamics and right ventricular function in the experimental model of secondary PH due to left heart disease and these drugs may offer a new therapeutic option for therapy of this condition.
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Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.
Michael Seimetz,Nirmal Parajuli,Alexandra Pichl,Mariola Bednorz,Hossein Ardeschir Ghofrani,Ralph T. Schermuly,Werner Seeger,Friedrich Grimminger,Norbert Weissmann +8 more
TL;DR: Preventive treatment with Tadalafil, Piclamilast or a combination of both almost completely prevented the development of emphysema, the increase in lung compliance, tidal volume, structural remodeling of the lung vasculature and right ventricular systolic pressure induced by cigarette smoke exposure.
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Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Soni Savai Pullamsetti,Daniel Maring,Hossein Ardeschir Ghofrani,Konstantin Mayer,Norbert Weissmann,Bernhard Rosengarten,Martin Lehner,Christian Schudt,Rainer Boer,Friedrich Grimminger,Werner Seeger,Ralph T. Schermuly +11 more
TL;DR: In a rat model of endotoxic shock selective iNOS inhibitors are superior to non-specific NOS inhibitors and in particular to norepinephrine for the treatment of macro- and microcirculatory abnormalities in experimental septic shock.
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Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro.
Katja Hattar,Christian P. Reinert,Ulf Sibelius,Mira Y. Gökyildirim,Florentine S.B. Subtil,Jochen Wilhelm,B. Eul,Gabriele Dahlem,Friedrich Grimminger,Werner Seeger,Werner Seeger,Ulrich Grandel +11 more
TL;DR: LTA of S. aureus induced proliferation of NSCLC cell lines of adeno- and squamous cell carcinoma origin, indicating that pulmonary infections may exert a direct pro-proliferative effect on lung cancer growth.