F
Fritz von Weizsäcker
Researcher at University of Freiburg
Publications - 48
Citations - 4187
Fritz von Weizsäcker is an academic researcher from University of Freiburg. The author has contributed to research in topics: Hepatitis B virus & Viral replication. The author has an hindex of 29, co-authored 48 publications receiving 4076 citations. Previous affiliations of Fritz von Weizsäcker include Humboldt University of Berlin & Harvard University.
Papers
More filters
Journal ArticleDOI
Cellular Binding of Hepatitis C Virus Envelope Glycoprotein E2 Requires Cell Surface Heparan Sulfate
Heidi Barth,Christiane Schäfer,Mohammed I. Adah,Fuming Zhang,Robert J. Linhardt,Hidenao Toyoda,Akiko Kinoshita-Toyoda,Toshihiko Toida,Toin H. van Kuppevelt,Erik Depla,Fritz von Weizsäcker,Hubert E. Blum,Thomas F. Baumert +12 more
TL;DR: It is demonstrated for the first time that cellular binding of HCV envelope requires E2-HSPG interaction, and docking of E2 to cellular HSPG may be the initial step in the interaction between HCV and the cell surface resulting in receptor-mediated entry and initiation of infection.
Journal ArticleDOI
p53 mutation in hepatocellular carcinoma after aflatoxin exposure
Brigitte Bressac,Alain Puisieux,Michael C. Kew,Martin Volkmann,Sema Bozcall,Jessika Bella Mura,Suzanne M. de la Monte,Rolf I. Carlson,Hubert E. Blum,Jack R. Wands,Hiroshi Takahashi,Fritz von Weizsäcker,Elthan Galun,Siddhartha Kar,BrianI. Carr,ClausH Schroder,Eren Erken,Seyhan Varinli,VinodK Rustgi,Jaime Prat,Gotaro Toda,HerbertK Koch,Xiao Huan Liang,Zhao-You Tang,Daniel Shouval,Hyo-Suk Lee,GirishN Vyas,Ildiko Sarosi,Mehmet Ozturk +28 more
TL;DR: A codon 249 mutation of the p53 gene identifies an endemic form of HCC strongly associated with dietary aflatoxin intake, which is correlated with high risk of exposure to aflatoxins and the hepatitis B virus.
Journal ArticleDOI
T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection
Tobias Boettler,Hans Christian Spangenberg,Christoph Neumann-Haefelin,Elisabeth Panther,S. Urbani,Carlo Ferrari,Hubert E. Blum,Fritz von Weizsäcker,Robert Thimme +8 more
TL;DR: It is suggested that chronic HCV infection leads to the expansion of CD4+CD25+ T cells that are able to suppress CD8+ T-cell responses to different viral antigens and may be a target for immunotherapy of chronic hepatitis C.
Journal ArticleDOI
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.
Joerg Petersen,Maura Dandri,Walter Mier,Marc Lütgehetmann,Tassilo Volz,Fritz von Weizsäcker,Uwe Haberkorn,Lutz Fischer,Joerg M. Pollok,Berit Erbes,Stefan Seitz,Stephan Urban +11 more
TL;DR: Inhibition of hepadnavirus entry constitutes a therapeutic approach to prevent primary HBV infection, such as after liver transplantation, and might also restrain virus spread in chronically infected patients.
Journal ArticleDOI
Pathogenesis of hepatitis B virus infection.
TL;DR: The impact of virus-host interactions for the pathogenesis of HBV infection and liver disease are discussed, including the relevance of naturally occurring viral variants for clinical disease, the role of viruses-induced apoptosis for HBV-induced liver cell injury and the impact of antiviral immune responses for outcome of infection.