Fujio Suzuki

TL;DR: The regulatory role of parathyroid hormone (PTH)/PTH-related peptide signaling has been implicated in embryonic skeletal development as discussed by the authors, and the expression of functional PTH/PTHrP receptor is associated with the onset of chondrogenesis in the early stages of endochondral bone development.

TL;DR: It is demonstrated that ATDC5 cells keep track of the multistep differentiation process encompassing the stages from mesenchymal condensation to calcification in vitro, as well as the molecular mechanism underlying regulation of cartilage differentiation during endochondral bone formation.

TL;DR: The results suggest that cartilage-matrix calcification can be controlled by growth factor(s) and that chondrocytes induce the mineralization of extracellular matrix when terminal differentiation is permitted in the absence of an artificial substrate.

TL;DR: A clonal cell line with cartilage phenotypes and tumorigenicity during more than 3 years in culture was established from a human chondrosarcoma, which consisted of slightly elongated polygonal cells, which proliferated with a doubling time of 3.5 days and formed nodules, which showed metachromasia when stained with toluidine blue.

TL;DR: P purification of an endothelial cell growth inhibitor from a guanidine extract of bovine epiphyseal cartilage suggests a regulatory role of ChM-I in vascular invasion during endochondral bone formation.