Identification of Chondromodulin I as a Novel Endothelial Cell Growth Inhibitor PURIFICATION AND ITS LOCALIZATION IN THE AVASCULAR ZONE OF EPIPHYSEAL CARTILAGE
Yuji Hiraki,Hiroyuki Inoue,Ken Ichi Iyama,Akihito Kamizono,Masanori Ochiai,Chisa Shukunami,Sadayo Iijima,Fujio Suzuki,Jun Kondo +8 more
TLDR
P purification of an endothelial cell growth inhibitor from a guanidine extract of bovine epiphyseal cartilage suggests a regulatory role of ChM-I in vascular invasion during endochondral bone formation.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-12-19 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Cartilage & Chondromodulin.read more
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Osteoarthritis, angiogenesis and inflammation
C.S. Bonnet,David A. Walsh +1 more
TL;DR: Evidence that angiogenesis and inflammation play an important role in the pathophysiology of OA is summarized and possible directions for future research into therapeutics that could effectively treat this disease are summarized.
Journal ArticleDOI
Maturational disturbance of chondrocytes in Cbfa1-deficient mice.
Masahiko Inada,Takahiro Yasui,Takahiro Yasui,Shintaro Nomura,Seigou Miyake,Kenji Deguchi,Miki Himeno,Motohiko Sato,Hiroshi Yamagiwa,Tomoatsu Kimura,Natuo Yasui,Takahiro Ochi,Naoto Endo,Yukihiko Kitamura,Tadamitsu Kishimoto,Toshihisa Komori,Toshihisa Komori +16 more
TL;DR: It is shown that Cbfa1 is an important factor for chondrocyte differentiation, and the expression of PTH/PTHrP receptor, Indian hedgehog, type X collagen, and BMP6 was not detected in humerus and femur, indicating that chondrodynamic differentiation was blocked before prehypertrophic chondROcytes.
Journal ArticleDOI
Systemic and Local Regulation of the Growth Plate
TL;DR: An update on the present perception of growth plate function and the regulation of chondrocyte proliferation and differentiation by systemic and local regulators of which most are now related to human growth disorders is presented.
Journal ArticleDOI
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
TL;DR: Results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chONDrocytes differentiation mediated by CbFA1.
Journal ArticleDOI
Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes
TL;DR: It is reported that TeM expression is closely associated with the appearance of tenocytes during chick development and is positively regulated by Scleraxis (Scx), and that Scx positively regulates TeMexpression in a tendon cell lineage-dependent manner.
References
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Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
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Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
Michael S. O'Reilly,Michael S. O'Reilly,Lars Holmgren,Lars Holmgren,Yuen Shing,Yuen Shing,Catherine Chen,Catherine Chen,Rosalind A. Rosenthal,Rosalind A. Rosenthal,Marsha A. Moses,Marsha A. Moses,William S. Lane,Yihai Cao,E. Helene Sage,Judah Folkman +15 more
TL;DR: It is shown that the inhibition of metastases by a primary mouse tumor is mediated, at least in part, by angiostatin, and a corresponding fragment of human plasminogen has similar activity.
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SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.
Y. Takebe,Motoharu Seiki,J.-I. Fujisawa,P. Hoy,K. Yokota,Ken-ichi Arai,Mitsuaki Yoshida,Naoko Arai +7 more
TL;DR: The SR alpha expression system was 1 or 2 orders of magnitude more active than the SV40 early promoter in a wide variety of cell types, including fibroblasts and lymphoid cells, and was capable of promoting a high level of expression of various lymphokine cDNAs.
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Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.
Theodore E. Maione,Gary S. Gray,Joan Petro,Anthony J. Hunt,Amy L. Donner,Susan I. Bauer,Helen F. Carson,Richard J. Sharpe,Richard J. Sharpe +8 more
TL;DR: Recombinant human platelet factor-4 (rhPF4), purified from Escherichia coli, inhibited blood vessel proliferation in the chicken chorioallantoic membrane in a dose-dependent manner and suggested that the angiostatic effect was due to specific inhibition of growth factor-stimulated endothelial cell proliferation.